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Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study

Some reports in the literature show the advantages of fluoride-containing apatite ceramics over hydroxyapatite (HAP), at least in some aspects. While HAP has been used extensively in the treatment of bone defects, fluoridated apatite has hardly been tested in vivo. In order to verify the biological...

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Autores principales: Borkowski, Leszek, Jojczuk, Mariusz, Belcarz, Anna, Pawlowska-Olszewska, Marta, Kruk-Bachonko, Joanna, Radzki, Radoslaw, Bienko, Marek, Slowik, Tymoteusz, Lübek, Tomasz, Nogalski, Adam, Ginalska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488477/
https://www.ncbi.nlm.nih.gov/pubmed/37687681
http://dx.doi.org/10.3390/ma16175992
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author Borkowski, Leszek
Jojczuk, Mariusz
Belcarz, Anna
Pawlowska-Olszewska, Marta
Kruk-Bachonko, Joanna
Radzki, Radoslaw
Bienko, Marek
Slowik, Tymoteusz
Lübek, Tomasz
Nogalski, Adam
Ginalska, Grazyna
author_facet Borkowski, Leszek
Jojczuk, Mariusz
Belcarz, Anna
Pawlowska-Olszewska, Marta
Kruk-Bachonko, Joanna
Radzki, Radoslaw
Bienko, Marek
Slowik, Tymoteusz
Lübek, Tomasz
Nogalski, Adam
Ginalska, Grazyna
author_sort Borkowski, Leszek
collection PubMed
description Some reports in the literature show the advantages of fluoride-containing apatite ceramics over hydroxyapatite (HAP), at least in some aspects. While HAP has been used extensively in the treatment of bone defects, fluoridated apatite has hardly been tested in vivo. In order to verify the biological properties of fluoride-doped apatite and to assess its therapeutic potential, we synthesized fluorapatite (FAP) and applied it as a filling in bone defects of experimental animals (rabbits). The treatment effects were evaluated on extracted bones after 3 and 6 months from implantation using peripheral quantitative computed tomography (pQCT), dual-energy X-ray absorptiometry (DXA), radiography (X-ray) and histological staining. The study proved the integration between FAP and the bone tissue, thus indicating its stimulating effect on new bone formation and mineralization. The results achieved after 3 months of treatment were difficult to interpret unequivocally and suggested the transient delay in FAP integration of bone in comparison with HAP. The reasons for this phenomenon are unclear. Most likely, these differences between FAP and HAP resulted mainly from the different porosities, densities and ionic reactivity of the ceramics, which in our opinion affected their solubility, integration and degree of bone tissue resorption. However, it was shown that 6 months after implantation, similar level of bone defect regeneration was achieved for both FAP and HAP. In this article, we present our hypothesis concerning the basis of this phenomenon.
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spelling pubmed-104884772023-09-09 Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study Borkowski, Leszek Jojczuk, Mariusz Belcarz, Anna Pawlowska-Olszewska, Marta Kruk-Bachonko, Joanna Radzki, Radoslaw Bienko, Marek Slowik, Tymoteusz Lübek, Tomasz Nogalski, Adam Ginalska, Grazyna Materials (Basel) Article Some reports in the literature show the advantages of fluoride-containing apatite ceramics over hydroxyapatite (HAP), at least in some aspects. While HAP has been used extensively in the treatment of bone defects, fluoridated apatite has hardly been tested in vivo. In order to verify the biological properties of fluoride-doped apatite and to assess its therapeutic potential, we synthesized fluorapatite (FAP) and applied it as a filling in bone defects of experimental animals (rabbits). The treatment effects were evaluated on extracted bones after 3 and 6 months from implantation using peripheral quantitative computed tomography (pQCT), dual-energy X-ray absorptiometry (DXA), radiography (X-ray) and histological staining. The study proved the integration between FAP and the bone tissue, thus indicating its stimulating effect on new bone formation and mineralization. The results achieved after 3 months of treatment were difficult to interpret unequivocally and suggested the transient delay in FAP integration of bone in comparison with HAP. The reasons for this phenomenon are unclear. Most likely, these differences between FAP and HAP resulted mainly from the different porosities, densities and ionic reactivity of the ceramics, which in our opinion affected their solubility, integration and degree of bone tissue resorption. However, it was shown that 6 months after implantation, similar level of bone defect regeneration was achieved for both FAP and HAP. In this article, we present our hypothesis concerning the basis of this phenomenon. MDPI 2023-08-31 /pmc/articles/PMC10488477/ /pubmed/37687681 http://dx.doi.org/10.3390/ma16175992 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borkowski, Leszek
Jojczuk, Mariusz
Belcarz, Anna
Pawlowska-Olszewska, Marta
Kruk-Bachonko, Joanna
Radzki, Radoslaw
Bienko, Marek
Slowik, Tymoteusz
Lübek, Tomasz
Nogalski, Adam
Ginalska, Grazyna
Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title_full Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title_fullStr Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title_full_unstemmed Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title_short Comparing the Healing Abilities of Fluorapatite and Hydroxyapatite Ceramics in Regenerating Bone Tissue: An In Vivo Study
title_sort comparing the healing abilities of fluorapatite and hydroxyapatite ceramics in regenerating bone tissue: an in vivo study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488477/
https://www.ncbi.nlm.nih.gov/pubmed/37687681
http://dx.doi.org/10.3390/ma16175992
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