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Unmet Challenges in Patients with Crohn’s Disease
Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488639/ https://www.ncbi.nlm.nih.gov/pubmed/37685662 http://dx.doi.org/10.3390/jcm12175595 |
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author | Scheurlen, Katharina M Parks, Mary A Macleod, Anne Galandiuk, Susan |
author_facet | Scheurlen, Katharina M Parks, Mary A Macleod, Anne Galandiuk, Susan |
author_sort | Scheurlen, Katharina M |
collection | PubMed |
description | Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was based on a literature search using PubMed, Embase, and Science Direct. Data on unmet challenges in patients with Crohn’s disease were extracted from identified manuscripts. The aim was to discuss present research on standardized processes in the management of patients with Crohn’s disease and to identify the unmet needs in clinical evaluation and treatment approaches. There is no consensus on standardized diagnostic, treatment, and surveillance algorithms, particularly in assessing complications of Crohn’s, such as stricturing disease, intestinal cancer risk, and cutaneous manifestations. Complications and treatment failure rates of conventional, interventional, and surgical therapy place emphasis on the need for standardized treatment algorithms, particularly in the case of acute complications of the disease. Research on standardized clinical approaches, reliable biomarkers for disease diagnosis and therapy monitoring, and new treatment agents is necessary to improve therapy and reduce complications in patients with Crohn’s disease. |
format | Online Article Text |
id | pubmed-10488639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104886392023-09-09 Unmet Challenges in Patients with Crohn’s Disease Scheurlen, Katharina M Parks, Mary A Macleod, Anne Galandiuk, Susan J Clin Med Review Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was based on a literature search using PubMed, Embase, and Science Direct. Data on unmet challenges in patients with Crohn’s disease were extracted from identified manuscripts. The aim was to discuss present research on standardized processes in the management of patients with Crohn’s disease and to identify the unmet needs in clinical evaluation and treatment approaches. There is no consensus on standardized diagnostic, treatment, and surveillance algorithms, particularly in assessing complications of Crohn’s, such as stricturing disease, intestinal cancer risk, and cutaneous manifestations. Complications and treatment failure rates of conventional, interventional, and surgical therapy place emphasis on the need for standardized treatment algorithms, particularly in the case of acute complications of the disease. Research on standardized clinical approaches, reliable biomarkers for disease diagnosis and therapy monitoring, and new treatment agents is necessary to improve therapy and reduce complications in patients with Crohn’s disease. MDPI 2023-08-27 /pmc/articles/PMC10488639/ /pubmed/37685662 http://dx.doi.org/10.3390/jcm12175595 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Scheurlen, Katharina M Parks, Mary A Macleod, Anne Galandiuk, Susan Unmet Challenges in Patients with Crohn’s Disease |
title | Unmet Challenges in Patients with Crohn’s Disease |
title_full | Unmet Challenges in Patients with Crohn’s Disease |
title_fullStr | Unmet Challenges in Patients with Crohn’s Disease |
title_full_unstemmed | Unmet Challenges in Patients with Crohn’s Disease |
title_short | Unmet Challenges in Patients with Crohn’s Disease |
title_sort | unmet challenges in patients with crohn’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488639/ https://www.ncbi.nlm.nih.gov/pubmed/37685662 http://dx.doi.org/10.3390/jcm12175595 |
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