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Unmet Challenges in Patients with Crohn’s Disease

Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was...

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Autores principales: Scheurlen, Katharina M, Parks, Mary A, Macleod, Anne, Galandiuk, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488639/
https://www.ncbi.nlm.nih.gov/pubmed/37685662
http://dx.doi.org/10.3390/jcm12175595
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author Scheurlen, Katharina M
Parks, Mary A
Macleod, Anne
Galandiuk, Susan
author_facet Scheurlen, Katharina M
Parks, Mary A
Macleod, Anne
Galandiuk, Susan
author_sort Scheurlen, Katharina M
collection PubMed
description Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was based on a literature search using PubMed, Embase, and Science Direct. Data on unmet challenges in patients with Crohn’s disease were extracted from identified manuscripts. The aim was to discuss present research on standardized processes in the management of patients with Crohn’s disease and to identify the unmet needs in clinical evaluation and treatment approaches. There is no consensus on standardized diagnostic, treatment, and surveillance algorithms, particularly in assessing complications of Crohn’s, such as stricturing disease, intestinal cancer risk, and cutaneous manifestations. Complications and treatment failure rates of conventional, interventional, and surgical therapy place emphasis on the need for standardized treatment algorithms, particularly in the case of acute complications of the disease. Research on standardized clinical approaches, reliable biomarkers for disease diagnosis and therapy monitoring, and new treatment agents is necessary to improve therapy and reduce complications in patients with Crohn’s disease.
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spelling pubmed-104886392023-09-09 Unmet Challenges in Patients with Crohn’s Disease Scheurlen, Katharina M Parks, Mary A Macleod, Anne Galandiuk, Susan J Clin Med Review Patients with Crohn’s disease can present with a variety of clinical manifestations; treatment strategies should focus on long-term remission and improvement of quality of life. There is no standardized process of diagnosing, predicting prognosis, and treating the disease. This narrative review was based on a literature search using PubMed, Embase, and Science Direct. Data on unmet challenges in patients with Crohn’s disease were extracted from identified manuscripts. The aim was to discuss present research on standardized processes in the management of patients with Crohn’s disease and to identify the unmet needs in clinical evaluation and treatment approaches. There is no consensus on standardized diagnostic, treatment, and surveillance algorithms, particularly in assessing complications of Crohn’s, such as stricturing disease, intestinal cancer risk, and cutaneous manifestations. Complications and treatment failure rates of conventional, interventional, and surgical therapy place emphasis on the need for standardized treatment algorithms, particularly in the case of acute complications of the disease. Research on standardized clinical approaches, reliable biomarkers for disease diagnosis and therapy monitoring, and new treatment agents is necessary to improve therapy and reduce complications in patients with Crohn’s disease. MDPI 2023-08-27 /pmc/articles/PMC10488639/ /pubmed/37685662 http://dx.doi.org/10.3390/jcm12175595 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scheurlen, Katharina M
Parks, Mary A
Macleod, Anne
Galandiuk, Susan
Unmet Challenges in Patients with Crohn’s Disease
title Unmet Challenges in Patients with Crohn’s Disease
title_full Unmet Challenges in Patients with Crohn’s Disease
title_fullStr Unmet Challenges in Patients with Crohn’s Disease
title_full_unstemmed Unmet Challenges in Patients with Crohn’s Disease
title_short Unmet Challenges in Patients with Crohn’s Disease
title_sort unmet challenges in patients with crohn’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488639/
https://www.ncbi.nlm.nih.gov/pubmed/37685662
http://dx.doi.org/10.3390/jcm12175595
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