Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation

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Huntington’s disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a result, many HTT-lowering therapies are being pursued in clinical studies, including those that reduce HTT RNA and protein expression in the liver. To investigate potential impacts, we characterized molecula...

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Detalles Bibliográficos
Autores principales: Bragg, Robert M, Coffey, Sydney R, Cantle, Jeffrey P, Hu, Shikai, Singh, Sucha, Legg, Samuel RW, McHugh, Cassandra A, Toor, Amreen, Zeitlin, Scott O, Kwak, Seung, Howland, David, Vogt, Thomas F, Monga, Satdarshan P, Carroll, Jeffrey B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488683/
https://www.ncbi.nlm.nih.gov/pubmed/37684045
http://dx.doi.org/10.26508/lsa.202302098
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