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Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery

Background: While reimbursement is centered on 90-day outcomes, many patients may still achieve optimal, long-term outcomes following adult spinal deformity (ASD) surgery despite transient short-term complications. Objective: Compare long-term clinical success and cost-utility between patients achie...

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Autores principales: Passias, Peter G., Williamson, Tyler K., Mir, Jamshaid M., Smith, Justin S., Lafage, Virginie, Lafage, Renaud, Line, Breton, Daniels, Alan H., Gum, Jeffrey L., Schoenfeld, Andrew J., Hamilton, David Kojo, Soroceanu, Alex, Scheer, Justin K., Eastlack, Robert, Mundis, Gregory M., Diebo, Bassel, Kebaish, Khaled M., Hostin, Richard A., Gupta, Munish C., Kim, Han Jo, Klineberg, Eric O., Ames, Christopher P., Hart, Robert A., Burton, Douglas C., Schwab, Frank J., Shaffrey, Christopher I., Bess, Shay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488913/
https://www.ncbi.nlm.nih.gov/pubmed/37685633
http://dx.doi.org/10.3390/jcm12175565
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author Passias, Peter G.
Williamson, Tyler K.
Mir, Jamshaid M.
Smith, Justin S.
Lafage, Virginie
Lafage, Renaud
Line, Breton
Daniels, Alan H.
Gum, Jeffrey L.
Schoenfeld, Andrew J.
Hamilton, David Kojo
Soroceanu, Alex
Scheer, Justin K.
Eastlack, Robert
Mundis, Gregory M.
Diebo, Bassel
Kebaish, Khaled M.
Hostin, Richard A.
Gupta, Munish C.
Kim, Han Jo
Klineberg, Eric O.
Ames, Christopher P.
Hart, Robert A.
Burton, Douglas C.
Schwab, Frank J.
Shaffrey, Christopher I.
Bess, Shay
author_facet Passias, Peter G.
Williamson, Tyler K.
Mir, Jamshaid M.
Smith, Justin S.
Lafage, Virginie
Lafage, Renaud
Line, Breton
Daniels, Alan H.
Gum, Jeffrey L.
Schoenfeld, Andrew J.
Hamilton, David Kojo
Soroceanu, Alex
Scheer, Justin K.
Eastlack, Robert
Mundis, Gregory M.
Diebo, Bassel
Kebaish, Khaled M.
Hostin, Richard A.
Gupta, Munish C.
Kim, Han Jo
Klineberg, Eric O.
Ames, Christopher P.
Hart, Robert A.
Burton, Douglas C.
Schwab, Frank J.
Shaffrey, Christopher I.
Bess, Shay
author_sort Passias, Peter G.
collection PubMed
description Background: While reimbursement is centered on 90-day outcomes, many patients may still achieve optimal, long-term outcomes following adult spinal deformity (ASD) surgery despite transient short-term complications. Objective: Compare long-term clinical success and cost-utility between patients achieving optimal realignment and suboptimally aligned peers. Study Design/Setting: Retrospective cohort study of a prospectively collected multicenter database. Methods: ASD patients with two-year (2Y) data included. Groups were propensity score matched (PSM) for age, frailty, body mass index (BMI), Charlson Comorbidity Index (CCI), and baseline deformity. Optimal radiographic criteria are defined as meeting low deformity in all three (Scoliosis Research Society) SRS-Schwab parameters or being proportioned in Global Alignment and Proportionality (GAP). Cost-per-QALY was calculated for each time point. Multivariable logistic regression analysis and ANCOVA (analysis of covariance) adjusting for baseline disability and deformity (pelvic incidence (PI), pelvic incidence minus lumbar lordosis (PI-LL)) were used to determine the significance of surgical details, complications, clinical outcomes, and cost-utility. Results: A total of 930 patients were considered. Following PSM, 253 “optimal” (O) and 253 “not optimal” (NO) patients were assessed. The O group underwent more invasive procedures and had more levels fused. Analysis of complications by two years showed that the O group suffered less overall major (38% vs. 52%, p = 0.021) and major mechanical complications (12% vs. 22%, p = 0.002), and less reoperations (23% vs. 33%, p = 0.008). Adjusted analysis revealed O patients more often met MCID (minimal clinically important difference) in SF-36 PCS, SRS-22 Pain, and Appearance. Cost-utility-adjusted analysis determined that the O group generated better cost-utility by one year and maintained lower overall cost and costs per QALY (both p < 0.001) at two years. Conclusions: Fewer late complications (mechanical and reoperations) are seen in optimally aligned patients, leading to better long-term cost-utility overall. Therefore, the current focus on avoiding short-term complications may be counterproductive, as achieving optimal surgical correction is critical for long-term success.
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spelling pubmed-104889132023-09-09 Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery Passias, Peter G. Williamson, Tyler K. Mir, Jamshaid M. Smith, Justin S. Lafage, Virginie Lafage, Renaud Line, Breton Daniels, Alan H. Gum, Jeffrey L. Schoenfeld, Andrew J. Hamilton, David Kojo Soroceanu, Alex Scheer, Justin K. Eastlack, Robert Mundis, Gregory M. Diebo, Bassel Kebaish, Khaled M. Hostin, Richard A. Gupta, Munish C. Kim, Han Jo Klineberg, Eric O. Ames, Christopher P. Hart, Robert A. Burton, Douglas C. Schwab, Frank J. Shaffrey, Christopher I. Bess, Shay J Clin Med Article Background: While reimbursement is centered on 90-day outcomes, many patients may still achieve optimal, long-term outcomes following adult spinal deformity (ASD) surgery despite transient short-term complications. Objective: Compare long-term clinical success and cost-utility between patients achieving optimal realignment and suboptimally aligned peers. Study Design/Setting: Retrospective cohort study of a prospectively collected multicenter database. Methods: ASD patients with two-year (2Y) data included. Groups were propensity score matched (PSM) for age, frailty, body mass index (BMI), Charlson Comorbidity Index (CCI), and baseline deformity. Optimal radiographic criteria are defined as meeting low deformity in all three (Scoliosis Research Society) SRS-Schwab parameters or being proportioned in Global Alignment and Proportionality (GAP). Cost-per-QALY was calculated for each time point. Multivariable logistic regression analysis and ANCOVA (analysis of covariance) adjusting for baseline disability and deformity (pelvic incidence (PI), pelvic incidence minus lumbar lordosis (PI-LL)) were used to determine the significance of surgical details, complications, clinical outcomes, and cost-utility. Results: A total of 930 patients were considered. Following PSM, 253 “optimal” (O) and 253 “not optimal” (NO) patients were assessed. The O group underwent more invasive procedures and had more levels fused. Analysis of complications by two years showed that the O group suffered less overall major (38% vs. 52%, p = 0.021) and major mechanical complications (12% vs. 22%, p = 0.002), and less reoperations (23% vs. 33%, p = 0.008). Adjusted analysis revealed O patients more often met MCID (minimal clinically important difference) in SF-36 PCS, SRS-22 Pain, and Appearance. Cost-utility-adjusted analysis determined that the O group generated better cost-utility by one year and maintained lower overall cost and costs per QALY (both p < 0.001) at two years. Conclusions: Fewer late complications (mechanical and reoperations) are seen in optimally aligned patients, leading to better long-term cost-utility overall. Therefore, the current focus on avoiding short-term complications may be counterproductive, as achieving optimal surgical correction is critical for long-term success. MDPI 2023-08-26 /pmc/articles/PMC10488913/ /pubmed/37685633 http://dx.doi.org/10.3390/jcm12175565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Passias, Peter G.
Williamson, Tyler K.
Mir, Jamshaid M.
Smith, Justin S.
Lafage, Virginie
Lafage, Renaud
Line, Breton
Daniels, Alan H.
Gum, Jeffrey L.
Schoenfeld, Andrew J.
Hamilton, David Kojo
Soroceanu, Alex
Scheer, Justin K.
Eastlack, Robert
Mundis, Gregory M.
Diebo, Bassel
Kebaish, Khaled M.
Hostin, Richard A.
Gupta, Munish C.
Kim, Han Jo
Klineberg, Eric O.
Ames, Christopher P.
Hart, Robert A.
Burton, Douglas C.
Schwab, Frank J.
Shaffrey, Christopher I.
Bess, Shay
Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title_full Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title_fullStr Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title_full_unstemmed Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title_short Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
title_sort are we focused on the wrong early postoperative quality metrics? optimal realignment outweighs perioperative risk in adult spinal deformity surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488913/
https://www.ncbi.nlm.nih.gov/pubmed/37685633
http://dx.doi.org/10.3390/jcm12175565
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