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Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases

Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nut...

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Autores principales: Yamashita, Shinji, Miyazawa, Taiki, Higuchi, Ohki, Kinoshita, Mikio, Miyazawa, Teruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488995/
https://www.ncbi.nlm.nih.gov/pubmed/37687157
http://dx.doi.org/10.3390/molecules28176328
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author Yamashita, Shinji
Miyazawa, Taiki
Higuchi, Ohki
Kinoshita, Mikio
Miyazawa, Teruo
author_facet Yamashita, Shinji
Miyazawa, Taiki
Higuchi, Ohki
Kinoshita, Mikio
Miyazawa, Teruo
author_sort Yamashita, Shinji
collection PubMed
description Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nutrients, and unique glycerophospholipid plasmalogens are found abundantly in some marine invertebrates, including ascidians. One of the major classes, the ethanolamine class (PlsEtn), exists in a high ratio to phospholipids in the brain and blood, while decreased levels have been reported in patients with age-associated diseases, including Alzheimer’s disease. Animal studies have shown that the administration of marine PlsEtn prepared from marine invertebrates improved PlsEtn levels in the body and alleviated inflammation. Animal and human studies have reported that marine PlsEtn ameliorates cognitive impairment. In this review, we highlight the biological significance, relationships with age-associated diseases, food functions, and healthcare materials of plasmalogens based on recent knowledge and discuss the contribution of marine plasmalogens to health maintenance in aging.
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spelling pubmed-104889952023-09-09 Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases Yamashita, Shinji Miyazawa, Taiki Higuchi, Ohki Kinoshita, Mikio Miyazawa, Teruo Molecules Review Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and clearance, thus leading to the development of age-associated diseases. The quality of our daily diet and exercise is important for the prevention of these diseases. Marine resources contain various valuable nutrients, and unique glycerophospholipid plasmalogens are found abundantly in some marine invertebrates, including ascidians. One of the major classes, the ethanolamine class (PlsEtn), exists in a high ratio to phospholipids in the brain and blood, while decreased levels have been reported in patients with age-associated diseases, including Alzheimer’s disease. Animal studies have shown that the administration of marine PlsEtn prepared from marine invertebrates improved PlsEtn levels in the body and alleviated inflammation. Animal and human studies have reported that marine PlsEtn ameliorates cognitive impairment. In this review, we highlight the biological significance, relationships with age-associated diseases, food functions, and healthcare materials of plasmalogens based on recent knowledge and discuss the contribution of marine plasmalogens to health maintenance in aging. MDPI 2023-08-29 /pmc/articles/PMC10488995/ /pubmed/37687157 http://dx.doi.org/10.3390/molecules28176328 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamashita, Shinji
Miyazawa, Taiki
Higuchi, Ohki
Kinoshita, Mikio
Miyazawa, Teruo
Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title_full Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title_fullStr Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title_full_unstemmed Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title_short Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases
title_sort marine plasmalogens: a gift from the sea with benefits for age-associated diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488995/
https://www.ncbi.nlm.nih.gov/pubmed/37687157
http://dx.doi.org/10.3390/molecules28176328
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