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Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries

Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17...

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Autores principales: Sisto, Margherita, Lisi, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489062/
https://www.ncbi.nlm.nih.gov/pubmed/37685766
http://dx.doi.org/10.3390/jcm12175699
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author Sisto, Margherita
Lisi, Sabrina
author_facet Sisto, Margherita
Lisi, Sabrina
author_sort Sisto, Margherita
collection PubMed
description Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17 (Th17) cells. Recent discoveries suggest a potential pro-fibrotic role for IL-23 in the development of chronic inflammatory autoimmune diseases characterized by intense fibrosis. In this review, we summarized the biological features of IL-23 and gathered recent research on the role of IL-23 in fibrotic autoimmune conditions, which could provide a theoretical basis for clinical targeting and drug development.
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spelling pubmed-104890622023-09-09 Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries Sisto, Margherita Lisi, Sabrina J Clin Med Review Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17 (Th17) cells. Recent discoveries suggest a potential pro-fibrotic role for IL-23 in the development of chronic inflammatory autoimmune diseases characterized by intense fibrosis. In this review, we summarized the biological features of IL-23 and gathered recent research on the role of IL-23 in fibrotic autoimmune conditions, which could provide a theoretical basis for clinical targeting and drug development. MDPI 2023-09-01 /pmc/articles/PMC10489062/ /pubmed/37685766 http://dx.doi.org/10.3390/jcm12175699 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sisto, Margherita
Lisi, Sabrina
Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title_full Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title_fullStr Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title_full_unstemmed Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title_short Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
title_sort interleukin-23 involved in fibrotic autoimmune diseases: new discoveries
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489062/
https://www.ncbi.nlm.nih.gov/pubmed/37685766
http://dx.doi.org/10.3390/jcm12175699
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