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Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries
Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489062/ https://www.ncbi.nlm.nih.gov/pubmed/37685766 http://dx.doi.org/10.3390/jcm12175699 |
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author | Sisto, Margherita Lisi, Sabrina |
author_facet | Sisto, Margherita Lisi, Sabrina |
author_sort | Sisto, Margherita |
collection | PubMed |
description | Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17 (Th17) cells. Recent discoveries suggest a potential pro-fibrotic role for IL-23 in the development of chronic inflammatory autoimmune diseases characterized by intense fibrosis. In this review, we summarized the biological features of IL-23 and gathered recent research on the role of IL-23 in fibrotic autoimmune conditions, which could provide a theoretical basis for clinical targeting and drug development. |
format | Online Article Text |
id | pubmed-10489062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104890622023-09-09 Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries Sisto, Margherita Lisi, Sabrina J Clin Med Review Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on immune responses. IL-23 is pathologically linked to the induction of the production of the pro-inflammatory cytokines IL-17 and IL-22, which stimulate the differentiation and proliferation of T helper type 17 (Th17) cells. Recent discoveries suggest a potential pro-fibrotic role for IL-23 in the development of chronic inflammatory autoimmune diseases characterized by intense fibrosis. In this review, we summarized the biological features of IL-23 and gathered recent research on the role of IL-23 in fibrotic autoimmune conditions, which could provide a theoretical basis for clinical targeting and drug development. MDPI 2023-09-01 /pmc/articles/PMC10489062/ /pubmed/37685766 http://dx.doi.org/10.3390/jcm12175699 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sisto, Margherita Lisi, Sabrina Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title | Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title_full | Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title_fullStr | Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title_full_unstemmed | Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title_short | Interleukin-23 Involved in Fibrotic Autoimmune Diseases: New Discoveries |
title_sort | interleukin-23 involved in fibrotic autoimmune diseases: new discoveries |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489062/ https://www.ncbi.nlm.nih.gov/pubmed/37685766 http://dx.doi.org/10.3390/jcm12175699 |
work_keys_str_mv | AT sistomargherita interleukin23involvedinfibroticautoimmunediseasesnewdiscoveries AT lisisabrina interleukin23involvedinfibroticautoimmunediseasesnewdiscoveries |