Cargando…

High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany

High serum thyroid-stimulating hormone (TSH) levels have previously been associated with a low estimated glomerular filtration rate (eGFR), but studies associating thyroid hormone levels with albuminuria revealed inconsistent results. We used cross-sectional data from 7933 individuals aged 20 to 93...

Descripción completa

Detalles Bibliográficos
Autores principales: Ittermann, Till, von Rheinbaben, Sabrina, Markus, Marcello R. P., Dörr, Marcus, Steveling, Antje, Nauck, Matthias, Teumer, Alexander, Gollasch, Maik, Spira, Dominik, König, Maximilian, Demuth, Ilja, Steinhagen-Thiessen, Elisabeth, Völzke, Henry, Stracke, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489120/
https://www.ncbi.nlm.nih.gov/pubmed/37685830
http://dx.doi.org/10.3390/jcm12175763
_version_ 1785103630490140672
author Ittermann, Till
von Rheinbaben, Sabrina
Markus, Marcello R. P.
Dörr, Marcus
Steveling, Antje
Nauck, Matthias
Teumer, Alexander
Gollasch, Maik
Spira, Dominik
König, Maximilian
Demuth, Ilja
Steinhagen-Thiessen, Elisabeth
Völzke, Henry
Stracke, Sylvia
author_facet Ittermann, Till
von Rheinbaben, Sabrina
Markus, Marcello R. P.
Dörr, Marcus
Steveling, Antje
Nauck, Matthias
Teumer, Alexander
Gollasch, Maik
Spira, Dominik
König, Maximilian
Demuth, Ilja
Steinhagen-Thiessen, Elisabeth
Völzke, Henry
Stracke, Sylvia
author_sort Ittermann, Till
collection PubMed
description High serum thyroid-stimulating hormone (TSH) levels have previously been associated with a low estimated glomerular filtration rate (eGFR), but studies associating thyroid hormone levels with albuminuria revealed inconsistent results. We used cross-sectional data from 7933 individuals aged 20 to 93 years of the Berlin Aging Study II and the Study of Health in Pomerania to associate serum TSH, fT3, and fT4 levels with eGFR and albuminuria. In multivariable analyses adjusted for confounding, we found inverse non-linear associations of serum TSH levels with eGFR, while serum fT3 levels showed a positive association with eGFR. High as well as low serum fT4 levels were associated with a lower eGFR. Age but not sex modified the association between thyroid hormone levels and eGFR. The inverse associations between serum TSH levels and eGFR were strongest in the youngest age groups, while the positive associations between serum fT3 levels and eGFR were strongest in older individuals. No significant associations between thyroid hormone levels and albuminuria were found. Our results indicate that hypothyroidism might be associated with a reduced kidney function. Thyroid function might be more tightly related to the eGFR than to albuminuria in the general population.
format Online
Article
Text
id pubmed-10489120
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104891202023-09-09 High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany Ittermann, Till von Rheinbaben, Sabrina Markus, Marcello R. P. Dörr, Marcus Steveling, Antje Nauck, Matthias Teumer, Alexander Gollasch, Maik Spira, Dominik König, Maximilian Demuth, Ilja Steinhagen-Thiessen, Elisabeth Völzke, Henry Stracke, Sylvia J Clin Med Article High serum thyroid-stimulating hormone (TSH) levels have previously been associated with a low estimated glomerular filtration rate (eGFR), but studies associating thyroid hormone levels with albuminuria revealed inconsistent results. We used cross-sectional data from 7933 individuals aged 20 to 93 years of the Berlin Aging Study II and the Study of Health in Pomerania to associate serum TSH, fT3, and fT4 levels with eGFR and albuminuria. In multivariable analyses adjusted for confounding, we found inverse non-linear associations of serum TSH levels with eGFR, while serum fT3 levels showed a positive association with eGFR. High as well as low serum fT4 levels were associated with a lower eGFR. Age but not sex modified the association between thyroid hormone levels and eGFR. The inverse associations between serum TSH levels and eGFR were strongest in the youngest age groups, while the positive associations between serum fT3 levels and eGFR were strongest in older individuals. No significant associations between thyroid hormone levels and albuminuria were found. Our results indicate that hypothyroidism might be associated with a reduced kidney function. Thyroid function might be more tightly related to the eGFR than to albuminuria in the general population. MDPI 2023-09-04 /pmc/articles/PMC10489120/ /pubmed/37685830 http://dx.doi.org/10.3390/jcm12175763 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ittermann, Till
von Rheinbaben, Sabrina
Markus, Marcello R. P.
Dörr, Marcus
Steveling, Antje
Nauck, Matthias
Teumer, Alexander
Gollasch, Maik
Spira, Dominik
König, Maximilian
Demuth, Ilja
Steinhagen-Thiessen, Elisabeth
Völzke, Henry
Stracke, Sylvia
High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title_full High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title_fullStr High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title_full_unstemmed High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title_short High Thyroid-Stimulating Hormone and Low Free Triiodothyronine Levels Are Associated with Chronic Kidney Disease in Three Population-Based Studies from Germany
title_sort high thyroid-stimulating hormone and low free triiodothyronine levels are associated with chronic kidney disease in three population-based studies from germany
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489120/
https://www.ncbi.nlm.nih.gov/pubmed/37685830
http://dx.doi.org/10.3390/jcm12175763
work_keys_str_mv AT ittermanntill highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT vonrheinbabensabrina highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT markusmarcellorp highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT dorrmarcus highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT stevelingantje highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT nauckmatthias highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT teumeralexander highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT gollaschmaik highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT spiradominik highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT konigmaximilian highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT demuthilja highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT steinhagenthiessenelisabeth highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT volzkehenry highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany
AT strackesylvia highthyroidstimulatinghormoneandlowfreetriiodothyroninelevelsareassociatedwithchronickidneydiseaseinthreepopulationbasedstudiesfromgermany