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Research progress of ferroptosis in Alzheimer disease: A review
Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation and reactive oxygen species (ROS). Alzheimer disease (AD), a neurodegenerative disorder, is characterized by the degeneration of nerve cells. Recent research has indicated a significant associatio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489260/ https://www.ncbi.nlm.nih.gov/pubmed/37682127 http://dx.doi.org/10.1097/MD.0000000000035142 |
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author | Han, Qi Sun, Li Xiang, Ke |
author_facet | Han, Qi Sun, Li Xiang, Ke |
author_sort | Han, Qi |
collection | PubMed |
description | Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation and reactive oxygen species (ROS). Alzheimer disease (AD), a neurodegenerative disorder, is characterized by the degeneration of nerve cells. Recent research has indicated a significant association between ferroptosis and AD; however, the precise underlying mechanism remains elusive. It is postulated that ferroptosis may impact the accumulation of iron ions within the body by influencing iron metabolism, amino acid metabolism, and lipid metabolism, ultimately leading to the induction of ferroptosis in nerve cells. This article centers on the attributes and regulatory mechanism of ferroptosis, the correlation between ferroptosis and AD, and the recent advancements in the therapeutic approach of targeting ferroptosis for the treatment of AD. These results suggest that ferroptosis could potentially serve as a pivotal focus in future research on AD. |
format | Online Article Text |
id | pubmed-10489260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104892602023-09-09 Research progress of ferroptosis in Alzheimer disease: A review Han, Qi Sun, Li Xiang, Ke Medicine (Baltimore) Research Article: Narrative Review Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation and reactive oxygen species (ROS). Alzheimer disease (AD), a neurodegenerative disorder, is characterized by the degeneration of nerve cells. Recent research has indicated a significant association between ferroptosis and AD; however, the precise underlying mechanism remains elusive. It is postulated that ferroptosis may impact the accumulation of iron ions within the body by influencing iron metabolism, amino acid metabolism, and lipid metabolism, ultimately leading to the induction of ferroptosis in nerve cells. This article centers on the attributes and regulatory mechanism of ferroptosis, the correlation between ferroptosis and AD, and the recent advancements in the therapeutic approach of targeting ferroptosis for the treatment of AD. These results suggest that ferroptosis could potentially serve as a pivotal focus in future research on AD. Lippincott Williams & Wilkins 2023-09-08 /pmc/articles/PMC10489260/ /pubmed/37682127 http://dx.doi.org/10.1097/MD.0000000000035142 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article: Narrative Review Han, Qi Sun, Li Xiang, Ke Research progress of ferroptosis in Alzheimer disease: A review |
title | Research progress of ferroptosis in Alzheimer disease: A review |
title_full | Research progress of ferroptosis in Alzheimer disease: A review |
title_fullStr | Research progress of ferroptosis in Alzheimer disease: A review |
title_full_unstemmed | Research progress of ferroptosis in Alzheimer disease: A review |
title_short | Research progress of ferroptosis in Alzheimer disease: A review |
title_sort | research progress of ferroptosis in alzheimer disease: a review |
topic | Research Article: Narrative Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489260/ https://www.ncbi.nlm.nih.gov/pubmed/37682127 http://dx.doi.org/10.1097/MD.0000000000035142 |
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