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Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization

This study aimed to investigate the impact of methodological factors on pregnancy rates after embryo transfer (ET) for in vitro fertilization. This retrospective cross-sectional study was conducted between September 2020 and April 2022. A total of 2048 patients who underwent ultrasonography-guided f...

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Autores principales: Kavrut, Mustecep, Sagir, Fulya Gokdagli, Atayurt, Zafer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489353/
https://www.ncbi.nlm.nih.gov/pubmed/37682170
http://dx.doi.org/10.1097/MD.0000000000035146
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author Kavrut, Mustecep
Sagir, Fulya Gokdagli
Atayurt, Zafer
author_facet Kavrut, Mustecep
Sagir, Fulya Gokdagli
Atayurt, Zafer
author_sort Kavrut, Mustecep
collection PubMed
description This study aimed to investigate the impact of methodological factors on pregnancy rates after embryo transfer (ET) for in vitro fertilization. This retrospective cross-sectional study was conducted between September 2020 and April 2022. A total of 2048 patients who underwent ultrasonography-guided first frozen embryo transfer (FET) or a fresh ET cycle due to infertility were included in the study. The effects of age, ET protocol (frozen or fresh), preimplantation genetic testing, number of embryos transferred (NET), and embryo fundus distance on pregnancy rate were investigated. The mean age of pregnant patients (31.51 ± 5.28) was significantly lower than that of non-pregnant patients (35.34 ± 6.39) (P < .001). Multiple regression analysis showed that women with lower age (P < .001), higher NET (P < .001), higher embryo fundus distance (P < .001), FET (P < .001), and preimplantation genetic testing (P = .012) had a significantly higher likelihood of pregnancy. Appropriate transfer depth, younger age, euploid embryo transfer, FET, and a higher NET can increase the likelihood of pregnancy. However, multiple factors must be considered when deciding the best protocol for a particular patient, including patient preference, costs and timing.
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spelling pubmed-104893532023-09-09 Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization Kavrut, Mustecep Sagir, Fulya Gokdagli Atayurt, Zafer Medicine (Baltimore) 5600 This study aimed to investigate the impact of methodological factors on pregnancy rates after embryo transfer (ET) for in vitro fertilization. This retrospective cross-sectional study was conducted between September 2020 and April 2022. A total of 2048 patients who underwent ultrasonography-guided first frozen embryo transfer (FET) or a fresh ET cycle due to infertility were included in the study. The effects of age, ET protocol (frozen or fresh), preimplantation genetic testing, number of embryos transferred (NET), and embryo fundus distance on pregnancy rate were investigated. The mean age of pregnant patients (31.51 ± 5.28) was significantly lower than that of non-pregnant patients (35.34 ± 6.39) (P < .001). Multiple regression analysis showed that women with lower age (P < .001), higher NET (P < .001), higher embryo fundus distance (P < .001), FET (P < .001), and preimplantation genetic testing (P = .012) had a significantly higher likelihood of pregnancy. Appropriate transfer depth, younger age, euploid embryo transfer, FET, and a higher NET can increase the likelihood of pregnancy. However, multiple factors must be considered when deciding the best protocol for a particular patient, including patient preference, costs and timing. Lippincott Williams & Wilkins 2023-09-08 /pmc/articles/PMC10489353/ /pubmed/37682170 http://dx.doi.org/10.1097/MD.0000000000035146 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5600
Kavrut, Mustecep
Sagir, Fulya Gokdagli
Atayurt, Zafer
Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title_full Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title_fullStr Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title_full_unstemmed Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title_short Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
title_sort large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489353/
https://www.ncbi.nlm.nih.gov/pubmed/37682170
http://dx.doi.org/10.1097/MD.0000000000035146
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