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Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review

Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti...

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Detalles Bibliográficos
Autores principales: Hao, Xiaoqing, Zhu, Xiaodi, Tian, Huiqun, Lai, Guanxi, Zhang, Wei, Zhou, Honghao, Liu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489489/
https://www.ncbi.nlm.nih.gov/pubmed/37682175
http://dx.doi.org/10.1097/MD.0000000000034671
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author Hao, Xiaoqing
Zhu, Xiaodi
Tian, Huiqun
Lai, Guanxi
Zhang, Wei
Zhou, Honghao
Liu, Song
author_facet Hao, Xiaoqing
Zhu, Xiaodi
Tian, Huiqun
Lai, Guanxi
Zhang, Wei
Zhou, Honghao
Liu, Song
author_sort Hao, Xiaoqing
collection PubMed
description Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells’ cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development.
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spelling pubmed-104894892023-09-09 Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review Hao, Xiaoqing Zhu, Xiaodi Tian, Huiqun Lai, Guanxi Zhang, Wei Zhou, Honghao Liu, Song Medicine (Baltimore) 5700 Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells’ cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development. Lippincott Williams & Wilkins 2023-09-08 /pmc/articles/PMC10489489/ /pubmed/37682175 http://dx.doi.org/10.1097/MD.0000000000034671 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5700
Hao, Xiaoqing
Zhu, Xiaodi
Tian, Huiqun
Lai, Guanxi
Zhang, Wei
Zhou, Honghao
Liu, Song
Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title_full Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title_fullStr Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title_full_unstemmed Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title_short Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
title_sort pharmacological effect and mechanism of orlistat in anti-tumor therapy: a review
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489489/
https://www.ncbi.nlm.nih.gov/pubmed/37682175
http://dx.doi.org/10.1097/MD.0000000000034671
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