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Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review
Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489489/ https://www.ncbi.nlm.nih.gov/pubmed/37682175 http://dx.doi.org/10.1097/MD.0000000000034671 |
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author | Hao, Xiaoqing Zhu, Xiaodi Tian, Huiqun Lai, Guanxi Zhang, Wei Zhou, Honghao Liu, Song |
author_facet | Hao, Xiaoqing Zhu, Xiaodi Tian, Huiqun Lai, Guanxi Zhang, Wei Zhou, Honghao Liu, Song |
author_sort | Hao, Xiaoqing |
collection | PubMed |
description | Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells’ cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development. |
format | Online Article Text |
id | pubmed-10489489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-104894892023-09-09 Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review Hao, Xiaoqing Zhu, Xiaodi Tian, Huiqun Lai, Guanxi Zhang, Wei Zhou, Honghao Liu, Song Medicine (Baltimore) 5700 Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells’ cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development. Lippincott Williams & Wilkins 2023-09-08 /pmc/articles/PMC10489489/ /pubmed/37682175 http://dx.doi.org/10.1097/MD.0000000000034671 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 5700 Hao, Xiaoqing Zhu, Xiaodi Tian, Huiqun Lai, Guanxi Zhang, Wei Zhou, Honghao Liu, Song Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title | Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title_full | Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title_fullStr | Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title_full_unstemmed | Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title_short | Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review |
title_sort | pharmacological effect and mechanism of orlistat in anti-tumor therapy: a review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489489/ https://www.ncbi.nlm.nih.gov/pubmed/37682175 http://dx.doi.org/10.1097/MD.0000000000034671 |
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