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Methodological Principles of Nasal Food Challenge
Thanks to their valuable assessment possibilities (subjective complaints and changes in nasal patency during the examination), nasal provocation tests may serve as an alternative tool for oral food challenges in the future. However, this test requires successive attempts to regulate its methodology...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489609/ https://www.ncbi.nlm.nih.gov/pubmed/37686848 http://dx.doi.org/10.3390/nu15173816 |
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author | Krzych-Fałta, Edyta Czerwińska, Monika E. Białek, Sławomir Furmańczyk, Konrad Samoliński, Bolesław Grodner, Błażej Sybilski, Adam Nowicka, Grażyna Wojas, Oksana |
author_facet | Krzych-Fałta, Edyta Czerwińska, Monika E. Białek, Sławomir Furmańczyk, Konrad Samoliński, Bolesław Grodner, Błażej Sybilski, Adam Nowicka, Grażyna Wojas, Oksana |
author_sort | Krzych-Fałta, Edyta |
collection | PubMed |
description | Thanks to their valuable assessment possibilities (subjective complaints and changes in nasal patency during the examination), nasal provocation tests may serve as an alternative tool for oral food challenges in the future. However, this test requires successive attempts to regulate its methodology in order to develop a standardized lyophilisate form and determine the threshold dose for a positive result. The study objective was to present the methodological foundation for nasal food allergen provocation tests induced by freeze-dried powdered chicken egg whites. A control group of 25 individuals with no history of allergy to chicken eggs or any other allergy was included in the study. Optical rhinometry and visual analog scales were used to assess the response of nasal mucosa to local allergen challenges. Minor variations in nasal flows, as measured by optical rhinometry, were observed in the provocation tests. The mean optical density measurements (as measured regardless of the allergen dose used) varied from positive to negative values and vice versa, e.g., amounting to 0.018 OD (standard deviation 0.095) at 15 min and −0.011 OD (standard deviation 0.090) at 30 min. No significant differences were observed concerning the perceived nasal discomfort using the visual analog scale. Due to the absence of nasal mucosal reactivity, nasal challenge is an excellent methodological tool for implementing food allergen tests. |
format | Online Article Text |
id | pubmed-10489609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104896092023-09-09 Methodological Principles of Nasal Food Challenge Krzych-Fałta, Edyta Czerwińska, Monika E. Białek, Sławomir Furmańczyk, Konrad Samoliński, Bolesław Grodner, Błażej Sybilski, Adam Nowicka, Grażyna Wojas, Oksana Nutrients Article Thanks to their valuable assessment possibilities (subjective complaints and changes in nasal patency during the examination), nasal provocation tests may serve as an alternative tool for oral food challenges in the future. However, this test requires successive attempts to regulate its methodology in order to develop a standardized lyophilisate form and determine the threshold dose for a positive result. The study objective was to present the methodological foundation for nasal food allergen provocation tests induced by freeze-dried powdered chicken egg whites. A control group of 25 individuals with no history of allergy to chicken eggs or any other allergy was included in the study. Optical rhinometry and visual analog scales were used to assess the response of nasal mucosa to local allergen challenges. Minor variations in nasal flows, as measured by optical rhinometry, were observed in the provocation tests. The mean optical density measurements (as measured regardless of the allergen dose used) varied from positive to negative values and vice versa, e.g., amounting to 0.018 OD (standard deviation 0.095) at 15 min and −0.011 OD (standard deviation 0.090) at 30 min. No significant differences were observed concerning the perceived nasal discomfort using the visual analog scale. Due to the absence of nasal mucosal reactivity, nasal challenge is an excellent methodological tool for implementing food allergen tests. MDPI 2023-08-31 /pmc/articles/PMC10489609/ /pubmed/37686848 http://dx.doi.org/10.3390/nu15173816 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Krzych-Fałta, Edyta Czerwińska, Monika E. Białek, Sławomir Furmańczyk, Konrad Samoliński, Bolesław Grodner, Błażej Sybilski, Adam Nowicka, Grażyna Wojas, Oksana Methodological Principles of Nasal Food Challenge |
title | Methodological Principles of Nasal Food Challenge |
title_full | Methodological Principles of Nasal Food Challenge |
title_fullStr | Methodological Principles of Nasal Food Challenge |
title_full_unstemmed | Methodological Principles of Nasal Food Challenge |
title_short | Methodological Principles of Nasal Food Challenge |
title_sort | methodological principles of nasal food challenge |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489609/ https://www.ncbi.nlm.nih.gov/pubmed/37686848 http://dx.doi.org/10.3390/nu15173816 |
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