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Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda

In low-income countries, undernutrition and infections play a major role in childhood anemia. Stunted children may be at particular risk of anemia. In a cross-sectional study nested in a nutrition trial among 12–59-month-old stunted children in eastern Uganda, we measured hemoglobin (Hb) and markers...

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Autores principales: Mutumba, Rolland, Mbabazi, Joseph, Pesu, Hannah, Greibe, Eva, Olsen, Mette F., Briend, André, Mølgaard, Christian, Ritz, Christian, Mupere, Ezekiel, Filteau, Suzanne, Friis, Henrik, Grenov, Benedikte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489905/
https://www.ncbi.nlm.nih.gov/pubmed/37686816
http://dx.doi.org/10.3390/nu15173785
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author Mutumba, Rolland
Mbabazi, Joseph
Pesu, Hannah
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
author_facet Mutumba, Rolland
Mbabazi, Joseph
Pesu, Hannah
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
author_sort Mutumba, Rolland
collection PubMed
description In low-income countries, undernutrition and infections play a major role in childhood anemia. Stunted children may be at particular risk of anemia. In a cross-sectional study nested in a nutrition trial among 12–59-month-old stunted children in eastern Uganda, we measured hemoglobin (Hb) and markers of iron, cobalamin, folate and vitamin A status. We assessed low micronutrient status, socio-demography, stunting severity, inflammation and malaria as correlates of Hb and anemia using linear and logistic regression analyses, respectively. Of 750 stunted children, the mean ± SD age was 32.0 ± 11.7 months and 55% (n = 412) were male. The mean Hb was 104 ± 15 g/L and 65% had anemia, Hb < 110 g/L. In a multivariable model with age, sex and inflammation, the following were associated with lower Hb: serum ferritin < 12 µg/L (−5.6 g/L, 95% CI: −8.6; −2.6), transferrin receptors > 8.3 mg/L (−6.2 g/L, 95% CI: −8.4; −4.0), plasma folate <20 nmol/L (−4.6 g/L, 95% CI: −8.1;−1.1), cobalamin < 222 pmol/L (−3.0 g/L, 95% CI: −5.4; −0.7) and serum retinol-binding protein < 0.7 µmol/L (−2.0 g/L, 95% CI: −4.1; 0.2). In addition, severe stunting, inflammation and malaria were negative correlates. Anemia is common among stunted children in eastern Uganda; micronutrient deficiencies, inflammation and malaria are associated with low Hb.
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spelling pubmed-104899052023-09-09 Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda Mutumba, Rolland Mbabazi, Joseph Pesu, Hannah Greibe, Eva Olsen, Mette F. Briend, André Mølgaard, Christian Ritz, Christian Mupere, Ezekiel Filteau, Suzanne Friis, Henrik Grenov, Benedikte Nutrients Article In low-income countries, undernutrition and infections play a major role in childhood anemia. Stunted children may be at particular risk of anemia. In a cross-sectional study nested in a nutrition trial among 12–59-month-old stunted children in eastern Uganda, we measured hemoglobin (Hb) and markers of iron, cobalamin, folate and vitamin A status. We assessed low micronutrient status, socio-demography, stunting severity, inflammation and malaria as correlates of Hb and anemia using linear and logistic regression analyses, respectively. Of 750 stunted children, the mean ± SD age was 32.0 ± 11.7 months and 55% (n = 412) were male. The mean Hb was 104 ± 15 g/L and 65% had anemia, Hb < 110 g/L. In a multivariable model with age, sex and inflammation, the following were associated with lower Hb: serum ferritin < 12 µg/L (−5.6 g/L, 95% CI: −8.6; −2.6), transferrin receptors > 8.3 mg/L (−6.2 g/L, 95% CI: −8.4; −4.0), plasma folate <20 nmol/L (−4.6 g/L, 95% CI: −8.1;−1.1), cobalamin < 222 pmol/L (−3.0 g/L, 95% CI: −5.4; −0.7) and serum retinol-binding protein < 0.7 µmol/L (−2.0 g/L, 95% CI: −4.1; 0.2). In addition, severe stunting, inflammation and malaria were negative correlates. Anemia is common among stunted children in eastern Uganda; micronutrient deficiencies, inflammation and malaria are associated with low Hb. MDPI 2023-08-30 /pmc/articles/PMC10489905/ /pubmed/37686816 http://dx.doi.org/10.3390/nu15173785 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mutumba, Rolland
Mbabazi, Joseph
Pesu, Hannah
Greibe, Eva
Olsen, Mette F.
Briend, André
Mølgaard, Christian
Ritz, Christian
Mupere, Ezekiel
Filteau, Suzanne
Friis, Henrik
Grenov, Benedikte
Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title_full Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title_fullStr Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title_full_unstemmed Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title_short Micronutrient Status and Other Correlates of Hemoglobin among Children with Stunting: A Cross-Sectional Study in Uganda
title_sort micronutrient status and other correlates of hemoglobin among children with stunting: a cross-sectional study in uganda
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489905/
https://www.ncbi.nlm.nih.gov/pubmed/37686816
http://dx.doi.org/10.3390/nu15173785
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