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Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases

Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for neuroprotection due to their immense antioxidant, anti-inflammatory, and anti-apoptotic properties. Neurodegenerative diseases (NDDs...

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Autores principales: Wankhede, Nitu L., Kale, Mayur B., Bawankule, Ashwini K., Aglawe, Manish M., Taksande, Brijesh G., Trivedi, Rashmi V., Umekar, Milind J., Jamadagni, Ankush, Walse, Prathamesh, Koppula, Sushruta, Kopalli, Spandana Rajendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489942/
https://www.ncbi.nlm.nih.gov/pubmed/37686782
http://dx.doi.org/10.3390/nu15173751
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author Wankhede, Nitu L.
Kale, Mayur B.
Bawankule, Ashwini K.
Aglawe, Manish M.
Taksande, Brijesh G.
Trivedi, Rashmi V.
Umekar, Milind J.
Jamadagni, Ankush
Walse, Prathamesh
Koppula, Sushruta
Kopalli, Spandana Rajendra
author_facet Wankhede, Nitu L.
Kale, Mayur B.
Bawankule, Ashwini K.
Aglawe, Manish M.
Taksande, Brijesh G.
Trivedi, Rashmi V.
Umekar, Milind J.
Jamadagni, Ankush
Walse, Prathamesh
Koppula, Sushruta
Kopalli, Spandana Rajendra
author_sort Wankhede, Nitu L.
collection PubMed
description Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for neuroprotection due to their immense antioxidant, anti-inflammatory, and anti-apoptotic properties. Neurodegenerative diseases (NDDs), characterized by the progressive degeneration of neurons, present a significant global health burden with limited therapeutic options. The phosphoinositide 3-kinase (PI3K) signaling pathway plays a crucial role in cell survival, growth, and metabolism, making it an attractive target for therapeutic intervention. The dysregulation of PI3K signaling has been implicated in the pathogenesis of various NDDs including Alzheimer’s and Parkinson’s disease. Avns have been shown to modulate PI3K/AKT signaling, leading to increased neuronal survival, reduced oxidative stress, and improved cognitive function. This review explores the potential of Avn polyphenols as modulators of the PI3K signaling pathway, focusing on their beneficial effects against NDDs. Further, we outline the need for clinical exploration to elucidate the specific mechanisms of Avn action on the PI3K/AKT pathway and its potential interactions with other signaling cascades involved in neurodegeneration. Based on the available literature, using relevant keywords from Google Scholar, PubMed, Scopus, Science Direct, and Web of Science, our review emphasizes the potential of using Avns as a therapeutic strategy for NDDs and warrants further investigation and clinical exploration.
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spelling pubmed-104899422023-09-09 Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases Wankhede, Nitu L. Kale, Mayur B. Bawankule, Ashwini K. Aglawe, Manish M. Taksande, Brijesh G. Trivedi, Rashmi V. Umekar, Milind J. Jamadagni, Ankush Walse, Prathamesh Koppula, Sushruta Kopalli, Spandana Rajendra Nutrients Review Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising candidates for neuroprotection due to their immense antioxidant, anti-inflammatory, and anti-apoptotic properties. Neurodegenerative diseases (NDDs), characterized by the progressive degeneration of neurons, present a significant global health burden with limited therapeutic options. The phosphoinositide 3-kinase (PI3K) signaling pathway plays a crucial role in cell survival, growth, and metabolism, making it an attractive target for therapeutic intervention. The dysregulation of PI3K signaling has been implicated in the pathogenesis of various NDDs including Alzheimer’s and Parkinson’s disease. Avns have been shown to modulate PI3K/AKT signaling, leading to increased neuronal survival, reduced oxidative stress, and improved cognitive function. This review explores the potential of Avn polyphenols as modulators of the PI3K signaling pathway, focusing on their beneficial effects against NDDs. Further, we outline the need for clinical exploration to elucidate the specific mechanisms of Avn action on the PI3K/AKT pathway and its potential interactions with other signaling cascades involved in neurodegeneration. Based on the available literature, using relevant keywords from Google Scholar, PubMed, Scopus, Science Direct, and Web of Science, our review emphasizes the potential of using Avns as a therapeutic strategy for NDDs and warrants further investigation and clinical exploration. MDPI 2023-08-27 /pmc/articles/PMC10489942/ /pubmed/37686782 http://dx.doi.org/10.3390/nu15173751 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wankhede, Nitu L.
Kale, Mayur B.
Bawankule, Ashwini K.
Aglawe, Manish M.
Taksande, Brijesh G.
Trivedi, Rashmi V.
Umekar, Milind J.
Jamadagni, Ankush
Walse, Prathamesh
Koppula, Sushruta
Kopalli, Spandana Rajendra
Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title_full Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title_fullStr Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title_full_unstemmed Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title_short Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases
title_sort overview on the polyphenol avenanthramide in oats (avena sativa linn.) as regulators of pi3k signaling in the management of neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489942/
https://www.ncbi.nlm.nih.gov/pubmed/37686782
http://dx.doi.org/10.3390/nu15173751
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