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In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review

The use of in vitro tissue culture for herbal medicines has been recognized as a valuable source of botanical secondary metabolites. The tissue culture of ginseng species is used in the production of bioactive compounds such as phenolics, polysaccharides, and especially ginsenosides, which are utili...

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Autores principales: Xu, Fengjiao, Valappil, Anjali Kariyarath, Mathiyalagan, Ramya, Tran, Thi Ngoc Anh, Ramadhania, Zelika Mega, Awais, Muhammad, Yang, Deok Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489967/
https://www.ncbi.nlm.nih.gov/pubmed/37687411
http://dx.doi.org/10.3390/plants12173165
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author Xu, Fengjiao
Valappil, Anjali Kariyarath
Mathiyalagan, Ramya
Tran, Thi Ngoc Anh
Ramadhania, Zelika Mega
Awais, Muhammad
Yang, Deok Chun
author_facet Xu, Fengjiao
Valappil, Anjali Kariyarath
Mathiyalagan, Ramya
Tran, Thi Ngoc Anh
Ramadhania, Zelika Mega
Awais, Muhammad
Yang, Deok Chun
author_sort Xu, Fengjiao
collection PubMed
description The use of in vitro tissue culture for herbal medicines has been recognized as a valuable source of botanical secondary metabolites. The tissue culture of ginseng species is used in the production of bioactive compounds such as phenolics, polysaccharides, and especially ginsenosides, which are utilized in the food, cosmetics, and pharmaceutical industries. This review paper focuses on the in vitro culture of Panax ginseng and accumulation of ginsenosides. In vitro culture has been applied to study organogenesis and biomass culture, and is involved in direct organogenesis for rooting and shooting from explants and in indirect morphogenesis for somatic embryogenesis via the callus, which is a mass of disorganized cells. Biomass production was conducted with different types of tissue cultures, such as adventitious roots, cell suspension, and hairy roots, and subsequently on a large scale in a bioreactor. This review provides the cumulative knowledge of biotechnological methods to increase the ginsenoside resources of P. ginseng. In addition, ginsenosides are summarized at enhanced levels of activity and content with elicitor treatment, together with perspectives of new breeding tools which can be developed in P. ginseng in the future.
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spelling pubmed-104899672023-09-09 In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review Xu, Fengjiao Valappil, Anjali Kariyarath Mathiyalagan, Ramya Tran, Thi Ngoc Anh Ramadhania, Zelika Mega Awais, Muhammad Yang, Deok Chun Plants (Basel) Review The use of in vitro tissue culture for herbal medicines has been recognized as a valuable source of botanical secondary metabolites. The tissue culture of ginseng species is used in the production of bioactive compounds such as phenolics, polysaccharides, and especially ginsenosides, which are utilized in the food, cosmetics, and pharmaceutical industries. This review paper focuses on the in vitro culture of Panax ginseng and accumulation of ginsenosides. In vitro culture has been applied to study organogenesis and biomass culture, and is involved in direct organogenesis for rooting and shooting from explants and in indirect morphogenesis for somatic embryogenesis via the callus, which is a mass of disorganized cells. Biomass production was conducted with different types of tissue cultures, such as adventitious roots, cell suspension, and hairy roots, and subsequently on a large scale in a bioreactor. This review provides the cumulative knowledge of biotechnological methods to increase the ginsenoside resources of P. ginseng. In addition, ginsenosides are summarized at enhanced levels of activity and content with elicitor treatment, together with perspectives of new breeding tools which can be developed in P. ginseng in the future. MDPI 2023-09-03 /pmc/articles/PMC10489967/ /pubmed/37687411 http://dx.doi.org/10.3390/plants12173165 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Fengjiao
Valappil, Anjali Kariyarath
Mathiyalagan, Ramya
Tran, Thi Ngoc Anh
Ramadhania, Zelika Mega
Awais, Muhammad
Yang, Deok Chun
In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title_full In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title_fullStr In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title_full_unstemmed In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title_short In Vitro Cultivation and Ginsenosides Accumulation in Panax ginseng: A Review
title_sort in vitro cultivation and ginsenosides accumulation in panax ginseng: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10489967/
https://www.ncbi.nlm.nih.gov/pubmed/37687411
http://dx.doi.org/10.3390/plants12173165
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