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Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

Gender-based medicine is attracting increasing interest every day, but studies on pediatric populations are still limited. In this setting, sex differences among patients undergoing total parenteral nutrition (TPN) have not been previously reported. This study investigated the presence of sex differ...

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Autores principales: De Nardi, Laura, Sala, Mariavittoria, Turoldo, Federico, Zanon, Davide, Maestro, Alessandra, Barbi, Egidio, Faganel Kotnik, Barbara, Maximova, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490019/
https://www.ncbi.nlm.nih.gov/pubmed/37686854
http://dx.doi.org/10.3390/nu15173822
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author De Nardi, Laura
Sala, Mariavittoria
Turoldo, Federico
Zanon, Davide
Maestro, Alessandra
Barbi, Egidio
Faganel Kotnik, Barbara
Maximova, Natalia
author_facet De Nardi, Laura
Sala, Mariavittoria
Turoldo, Federico
Zanon, Davide
Maestro, Alessandra
Barbi, Egidio
Faganel Kotnik, Barbara
Maximova, Natalia
author_sort De Nardi, Laura
collection PubMed
description Gender-based medicine is attracting increasing interest every day, but studies on pediatric populations are still limited. In this setting, sex differences among patients undergoing total parenteral nutrition (TPN) have not been previously reported. This study investigated the presence of sex differences in parenteral nutrition composition and outcomes among a cohort of pediatric patients admitted at the Oncohematology and Bone Marrow Transplant Unit of the Institute for Maternal and Child Health “Burlo Garofolo” of Trieste, Italy. For all 145 recruited patients (87 males, 58 females), the following data were collected: age, sex, volume and duration of TPN, macro- and micronutrient composition of TPN bags, electrolytic or blood gases imbalance, glycolipid alterations, liver damage during TPN, and the incidence of sepsis and thrombosis. The analysis showed that females required higher daily phosphate intake (p = 0.054) and essential amino acid supplementation (p = 0.07), while males had a higher incidence of hypertriglyceridemia (p < 0.05) and cholestasis. A higher incidence of sepsis was found in the non-transplanted male population (p < 0.05). No significant differences were appreciable in other analyzed variables. This study aims to create a basis for future gender-based nutritional recommendations in the pediatric field.
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spelling pubmed-104900192023-09-09 Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences? De Nardi, Laura Sala, Mariavittoria Turoldo, Federico Zanon, Davide Maestro, Alessandra Barbi, Egidio Faganel Kotnik, Barbara Maximova, Natalia Nutrients Article Gender-based medicine is attracting increasing interest every day, but studies on pediatric populations are still limited. In this setting, sex differences among patients undergoing total parenteral nutrition (TPN) have not been previously reported. This study investigated the presence of sex differences in parenteral nutrition composition and outcomes among a cohort of pediatric patients admitted at the Oncohematology and Bone Marrow Transplant Unit of the Institute for Maternal and Child Health “Burlo Garofolo” of Trieste, Italy. For all 145 recruited patients (87 males, 58 females), the following data were collected: age, sex, volume and duration of TPN, macro- and micronutrient composition of TPN bags, electrolytic or blood gases imbalance, glycolipid alterations, liver damage during TPN, and the incidence of sepsis and thrombosis. The analysis showed that females required higher daily phosphate intake (p = 0.054) and essential amino acid supplementation (p = 0.07), while males had a higher incidence of hypertriglyceridemia (p < 0.05) and cholestasis. A higher incidence of sepsis was found in the non-transplanted male population (p < 0.05). No significant differences were appreciable in other analyzed variables. This study aims to create a basis for future gender-based nutritional recommendations in the pediatric field. MDPI 2023-08-31 /pmc/articles/PMC10490019/ /pubmed/37686854 http://dx.doi.org/10.3390/nu15173822 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Nardi, Laura
Sala, Mariavittoria
Turoldo, Federico
Zanon, Davide
Maestro, Alessandra
Barbi, Egidio
Faganel Kotnik, Barbara
Maximova, Natalia
Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title_full Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title_fullStr Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title_full_unstemmed Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title_short Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?
title_sort parenteral nutrition in the pediatric oncologic population: are there any sex differences?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490019/
https://www.ncbi.nlm.nih.gov/pubmed/37686854
http://dx.doi.org/10.3390/nu15173822
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