Cargando…

Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems

Micro- and nanotechnologies have been intensively studied in recent years as novel platforms for targeting and controlling the delivery of various pharmaceutical substances. Microparticulate drug delivery systems for oral, parenteral, or topical administration are multiple unit formulations, conside...

Descripción completa

Detalles Bibliográficos
Autores principales: Lukova, Paolina, Katsarov, Plamen, Pilicheva, Bissera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490215/
https://www.ncbi.nlm.nih.gov/pubmed/37688241
http://dx.doi.org/10.3390/polym15173615
_version_ 1785103792298000384
author Lukova, Paolina
Katsarov, Plamen
Pilicheva, Bissera
author_facet Lukova, Paolina
Katsarov, Plamen
Pilicheva, Bissera
author_sort Lukova, Paolina
collection PubMed
description Micro- and nanotechnologies have been intensively studied in recent years as novel platforms for targeting and controlling the delivery of various pharmaceutical substances. Microparticulate drug delivery systems for oral, parenteral, or topical administration are multiple unit formulations, considered as powerful therapeutic tools for the treatment of various diseases, providing sustained drug release, enhanced drug stability, and precise dosing and directing the active substance to specific sites in the organism. The properties of these pharmaceutical formulations are highly dependent on the characteristics of the polymers used as drug carriers for their preparation. Starch and cellulose are among the most preferred biomaterials for biomedical applications due to their biocompatibility, biodegradability, and lack of toxicity. These polysaccharides and their derivatives, like dextrins (maltodextrin, cyclodextrins), ethylcellulose, methylcellulose, hydroxypropyl methylcellulose, carboxy methylcellulose, etc., have been widely used in pharmaceutical technology as excipients for the preparation of solid, semi-solid, and liquid dosage forms. Due to their accessibility and relatively easy particle-forming properties, starch and cellulose are promising materials for designing drug-loaded microparticles for various therapeutic applications. This study aims to summarize some of the basic characteristics of starch and cellulose derivatives related to their potential utilization as microparticulate drug carriers in the pharmaceutical field.
format Online
Article
Text
id pubmed-10490215
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-104902152023-09-09 Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems Lukova, Paolina Katsarov, Plamen Pilicheva, Bissera Polymers (Basel) Review Micro- and nanotechnologies have been intensively studied in recent years as novel platforms for targeting and controlling the delivery of various pharmaceutical substances. Microparticulate drug delivery systems for oral, parenteral, or topical administration are multiple unit formulations, considered as powerful therapeutic tools for the treatment of various diseases, providing sustained drug release, enhanced drug stability, and precise dosing and directing the active substance to specific sites in the organism. The properties of these pharmaceutical formulations are highly dependent on the characteristics of the polymers used as drug carriers for their preparation. Starch and cellulose are among the most preferred biomaterials for biomedical applications due to their biocompatibility, biodegradability, and lack of toxicity. These polysaccharides and their derivatives, like dextrins (maltodextrin, cyclodextrins), ethylcellulose, methylcellulose, hydroxypropyl methylcellulose, carboxy methylcellulose, etc., have been widely used in pharmaceutical technology as excipients for the preparation of solid, semi-solid, and liquid dosage forms. Due to their accessibility and relatively easy particle-forming properties, starch and cellulose are promising materials for designing drug-loaded microparticles for various therapeutic applications. This study aims to summarize some of the basic characteristics of starch and cellulose derivatives related to their potential utilization as microparticulate drug carriers in the pharmaceutical field. MDPI 2023-08-31 /pmc/articles/PMC10490215/ /pubmed/37688241 http://dx.doi.org/10.3390/polym15173615 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lukova, Paolina
Katsarov, Plamen
Pilicheva, Bissera
Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title_full Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title_fullStr Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title_full_unstemmed Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title_short Application of Starch, Cellulose, and Their Derivatives in the Development of Microparticle Drug-Delivery Systems
title_sort application of starch, cellulose, and their derivatives in the development of microparticle drug-delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490215/
https://www.ncbi.nlm.nih.gov/pubmed/37688241
http://dx.doi.org/10.3390/polym15173615
work_keys_str_mv AT lukovapaolina applicationofstarchcelluloseandtheirderivativesinthedevelopmentofmicroparticledrugdeliverysystems
AT katsarovplamen applicationofstarchcelluloseandtheirderivativesinthedevelopmentofmicroparticledrugdeliverysystems
AT pilichevabissera applicationofstarchcelluloseandtheirderivativesinthedevelopmentofmicroparticledrugdeliverysystems