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Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study
Chronic pain is a prevalent and debilitating condition with significant impacts on individuals and society. While the role of diet in chronic pain is well-known, the relationship between special dietary choices and chronic pain remains unclear. This study investigates the causal associations between...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490345/ https://www.ncbi.nlm.nih.gov/pubmed/37686741 http://dx.doi.org/10.3390/nu15173709 |
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author | Zhou, Ren Zhang, Lei Sun, Yu Yan, Jia Jiang, Hong |
author_facet | Zhou, Ren Zhang, Lei Sun, Yu Yan, Jia Jiang, Hong |
author_sort | Zhou, Ren |
collection | PubMed |
description | Chronic pain is a prevalent and debilitating condition with significant impacts on individuals and society. While the role of diet in chronic pain is well-known, the relationship between special dietary choices and chronic pain remains unclear. This study investigates the causal associations between 20 dietary habits and chronic pain using a Mendelian randomization (MR) approach. Publicly available genome-wide association study data from the UK Biobank dataset were utilized for secondary analysis, and genetic instrumental variables strongly correlated with 20 different dietary habits were selected. Multisite chronic pain (MCP) scores were used as the primary outcome, with site-specific chronic pain (SSCP) including back pain, headache, knee pain, neck pain, and hip pain as secondary outcomes. The inverse-variance-weighted (IVW) method was the primary method used in the MR. The weighted median (WM) and Mendelian randomization pleiotropy residual sum and outlier test (MR-PRESSO) methods were used as sensitivity analyses. This study identified causal associations between specific dietary habits and chronic pain. A high intake of cheese, cereal, dried fruits, and fresh fruits was associated with lower MCP scores. Conversely, high alcohol, salt, pork, and poultry intakes were associated with higher MCP scores. Similar associations between special dietary habits and some types of SSCP, such as back and neck pain, were also observed. The findings were consistent across different statistical methods, and sensitivity analyses confirmed the reliability of the results. In conclusion, our study provides evidence of a causal relationship between various dietary habits and different types of chronic pain based on secondary analysis of the UK Biobank dataset. Adhering to an anti-inflammatory diet, including increased consumption of fruits and cereal while reducing salt and pork intake, may potentially alleviate chronic pain symptoms. |
format | Online Article Text |
id | pubmed-10490345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104903452023-09-09 Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study Zhou, Ren Zhang, Lei Sun, Yu Yan, Jia Jiang, Hong Nutrients Article Chronic pain is a prevalent and debilitating condition with significant impacts on individuals and society. While the role of diet in chronic pain is well-known, the relationship between special dietary choices and chronic pain remains unclear. This study investigates the causal associations between 20 dietary habits and chronic pain using a Mendelian randomization (MR) approach. Publicly available genome-wide association study data from the UK Biobank dataset were utilized for secondary analysis, and genetic instrumental variables strongly correlated with 20 different dietary habits were selected. Multisite chronic pain (MCP) scores were used as the primary outcome, with site-specific chronic pain (SSCP) including back pain, headache, knee pain, neck pain, and hip pain as secondary outcomes. The inverse-variance-weighted (IVW) method was the primary method used in the MR. The weighted median (WM) and Mendelian randomization pleiotropy residual sum and outlier test (MR-PRESSO) methods were used as sensitivity analyses. This study identified causal associations between specific dietary habits and chronic pain. A high intake of cheese, cereal, dried fruits, and fresh fruits was associated with lower MCP scores. Conversely, high alcohol, salt, pork, and poultry intakes were associated with higher MCP scores. Similar associations between special dietary habits and some types of SSCP, such as back and neck pain, were also observed. The findings were consistent across different statistical methods, and sensitivity analyses confirmed the reliability of the results. In conclusion, our study provides evidence of a causal relationship between various dietary habits and different types of chronic pain based on secondary analysis of the UK Biobank dataset. Adhering to an anti-inflammatory diet, including increased consumption of fruits and cereal while reducing salt and pork intake, may potentially alleviate chronic pain symptoms. MDPI 2023-08-24 /pmc/articles/PMC10490345/ /pubmed/37686741 http://dx.doi.org/10.3390/nu15173709 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Ren Zhang, Lei Sun, Yu Yan, Jia Jiang, Hong Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title | Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title_full | Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title_fullStr | Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title_full_unstemmed | Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title_short | Causal Associations between Dietary Habits and Chronic Pain: A Two-Sample Mendelian Randomization Study |
title_sort | causal associations between dietary habits and chronic pain: a two-sample mendelian randomization study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490345/ https://www.ncbi.nlm.nih.gov/pubmed/37686741 http://dx.doi.org/10.3390/nu15173709 |
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