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Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age
The effective management of the 33 million children with moderate acute malnutrition (MAM) is key to reducing childhood morbidity and mortality. In this review, we aim to evaluate the effectiveness of specially formulated foods (SFFs) compared to non-food-based approaches to manage MAM in children &...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490450/ https://www.ncbi.nlm.nih.gov/pubmed/37686813 http://dx.doi.org/10.3390/nu15173781 |
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author | Padhani, Zahra A. Cichon, Bernardette Das, Jai K. Salam, Rehana A. Stobaugh, Heather C. Mughal, Muzna Rutishauser-Perera, Alexandra Black, Robert E. Bhutta, Zulfiqar A. |
author_facet | Padhani, Zahra A. Cichon, Bernardette Das, Jai K. Salam, Rehana A. Stobaugh, Heather C. Mughal, Muzna Rutishauser-Perera, Alexandra Black, Robert E. Bhutta, Zulfiqar A. |
author_sort | Padhani, Zahra A. |
collection | PubMed |
description | The effective management of the 33 million children with moderate acute malnutrition (MAM) is key to reducing childhood morbidity and mortality. In this review, we aim to evaluate the effectiveness of specially formulated foods (SFFs) compared to non-food-based approaches to manage MAM in children >6 months old. We conducted a search on ten databases until 23 August 2021 and included five studies, covering 3387 participants. Meta-analysis of four studies comparing SFFs to counselling or standard of care showed that SFFs likely increase recovery rate, reduce non-response, and may improve weight-for-height z-score, weight-for-age z-score and time to recovery, but have little or no effect on MUAC gain. One study on a multicomponent intervention (SFFs, antibiotics and counselling provided to high-risk MAM) compared to counselling only was reported narratively. The intervention may increase weight gain after 24 weeks but may have little or no effect on weight gain after 12 weeks and on non-response and mortality after 12 and 24 weeks of enrollment. The effect of this intervention on recovery was uncertain. In conclusion, SFFs may be beneficial for children with moderate wasting in humanitarian contexts. Programmatic recommendations should consider context and cost-effectiveness. |
format | Online Article Text |
id | pubmed-10490450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-104904502023-09-09 Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age Padhani, Zahra A. Cichon, Bernardette Das, Jai K. Salam, Rehana A. Stobaugh, Heather C. Mughal, Muzna Rutishauser-Perera, Alexandra Black, Robert E. Bhutta, Zulfiqar A. Nutrients Review The effective management of the 33 million children with moderate acute malnutrition (MAM) is key to reducing childhood morbidity and mortality. In this review, we aim to evaluate the effectiveness of specially formulated foods (SFFs) compared to non-food-based approaches to manage MAM in children >6 months old. We conducted a search on ten databases until 23 August 2021 and included five studies, covering 3387 participants. Meta-analysis of four studies comparing SFFs to counselling or standard of care showed that SFFs likely increase recovery rate, reduce non-response, and may improve weight-for-height z-score, weight-for-age z-score and time to recovery, but have little or no effect on MUAC gain. One study on a multicomponent intervention (SFFs, antibiotics and counselling provided to high-risk MAM) compared to counselling only was reported narratively. The intervention may increase weight gain after 24 weeks but may have little or no effect on weight gain after 12 weeks and on non-response and mortality after 12 and 24 weeks of enrollment. The effect of this intervention on recovery was uncertain. In conclusion, SFFs may be beneficial for children with moderate wasting in humanitarian contexts. Programmatic recommendations should consider context and cost-effectiveness. MDPI 2023-08-30 /pmc/articles/PMC10490450/ /pubmed/37686813 http://dx.doi.org/10.3390/nu15173781 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Padhani, Zahra A. Cichon, Bernardette Das, Jai K. Salam, Rehana A. Stobaugh, Heather C. Mughal, Muzna Rutishauser-Perera, Alexandra Black, Robert E. Bhutta, Zulfiqar A. Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title | Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title_full | Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title_fullStr | Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title_full_unstemmed | Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title_short | Systematic Review of Management of Moderate Wasting in Children over 6 Months of Age |
title_sort | systematic review of management of moderate wasting in children over 6 months of age |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490450/ https://www.ncbi.nlm.nih.gov/pubmed/37686813 http://dx.doi.org/10.3390/nu15173781 |
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