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Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels

Background: Whether the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) dietary recommendations affect the gut microbiota and inflammatory status remains unclear. We examined the association of dietary adherence scores to the WCRF/AICR with gut microbiota and in...

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Autores principales: Wang, Dan, Meng, Sijia, Li, Jiqiu, Zhao, Jing, Wang, Yu, Du, Meizhi, Wang, Yuan, Lu, Wenli, Zhu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490500/
https://www.ncbi.nlm.nih.gov/pubmed/37686736
http://dx.doi.org/10.3390/nu15173705
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author Wang, Dan
Meng, Sijia
Li, Jiqiu
Zhao, Jing
Wang, Yu
Du, Meizhi
Wang, Yuan
Lu, Wenli
Zhu, Yun
author_facet Wang, Dan
Meng, Sijia
Li, Jiqiu
Zhao, Jing
Wang, Yu
Du, Meizhi
Wang, Yuan
Lu, Wenli
Zhu, Yun
author_sort Wang, Dan
collection PubMed
description Background: Whether the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) dietary recommendations affect the gut microbiota and inflammatory status remains unclear. We examined the association of dietary adherence scores to the WCRF/AICR with gut microbiota and inflammation in a cross-sectional setting. Methods: The WCRF/AICR diet adherence scores were calculated for 151 participants (adenoma 97, non-adenoma 54) from 7-day dietary records. The gut microbiota was analyzed by 16S rRNA gene sequencing of fecal samples. The levels of inflammatory biomarkers in both blood (i.e., IL-6, IL-8, IgA, IgM, and IgG) and fecal samples (i.e., FCP) were evaluated in 97 colorectal adenoma patients who had blood samples available. Multivariable linear regression analyses were conducted to examine the association of individual and total dietary adherence scores with gut microbiota and inflammatory biomarker levels. Results: Participants with higher adherence had lower relative abundance of Proteobacteria (β = −0.041, 95%CI: −0.073, −0.009), Enterobacteriaceae (β = −0.035, 95%CI: −0.067, −0.003), and unidentified Enterobacteriaceae at the genus level (β = −0.029, 95%CI: −0.055, −0.003) compared to those with lower adherence. Plant-based food intake was positively correlated with increased abundance of Phascolarctobacterium (β = 0.013, 95%CI: 0.001, 0.026). Restricting fast food was linked to high abundance of Bacteroidaceae (β = 0.149, 95%CI: 0.040, 0.257) and Bacteroides (β = 0.149, 95%CI: 0.040, 0.257). Limiting sugary drinks was associated with reduced abundance of Lachnospiraceae (β = −0.155, 95%CI: −0.292, −0.018). Plant-based food intake (β = −0.251, 95%CI: −0.450, −0.052) and restriction of fast food (β = −0.226, 95%CI: −0.443, −0.008) were associated with reduced IGG levels in men. Alcohol restriction was linked to lower IL-6 (β = −7.095, 95%CI: −11.286, −2.903) and IL-8 (β = −7.965, 95%CI: −14.700, −1.230) levels in women, but with higher IL-6 (β = 0.918, 95%CI: 0.161, 1.675) levels in men. Conclusions: Our findings support the association of adherence to the WCRF/AICR diet with gut microbiota and inflammation. These results need to be validated in additional prospective or interventional studies.
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spelling pubmed-104905002023-09-09 Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels Wang, Dan Meng, Sijia Li, Jiqiu Zhao, Jing Wang, Yu Du, Meizhi Wang, Yuan Lu, Wenli Zhu, Yun Nutrients Article Background: Whether the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) dietary recommendations affect the gut microbiota and inflammatory status remains unclear. We examined the association of dietary adherence scores to the WCRF/AICR with gut microbiota and inflammation in a cross-sectional setting. Methods: The WCRF/AICR diet adherence scores were calculated for 151 participants (adenoma 97, non-adenoma 54) from 7-day dietary records. The gut microbiota was analyzed by 16S rRNA gene sequencing of fecal samples. The levels of inflammatory biomarkers in both blood (i.e., IL-6, IL-8, IgA, IgM, and IgG) and fecal samples (i.e., FCP) were evaluated in 97 colorectal adenoma patients who had blood samples available. Multivariable linear regression analyses were conducted to examine the association of individual and total dietary adherence scores with gut microbiota and inflammatory biomarker levels. Results: Participants with higher adherence had lower relative abundance of Proteobacteria (β = −0.041, 95%CI: −0.073, −0.009), Enterobacteriaceae (β = −0.035, 95%CI: −0.067, −0.003), and unidentified Enterobacteriaceae at the genus level (β = −0.029, 95%CI: −0.055, −0.003) compared to those with lower adherence. Plant-based food intake was positively correlated with increased abundance of Phascolarctobacterium (β = 0.013, 95%CI: 0.001, 0.026). Restricting fast food was linked to high abundance of Bacteroidaceae (β = 0.149, 95%CI: 0.040, 0.257) and Bacteroides (β = 0.149, 95%CI: 0.040, 0.257). Limiting sugary drinks was associated with reduced abundance of Lachnospiraceae (β = −0.155, 95%CI: −0.292, −0.018). Plant-based food intake (β = −0.251, 95%CI: −0.450, −0.052) and restriction of fast food (β = −0.226, 95%CI: −0.443, −0.008) were associated with reduced IGG levels in men. Alcohol restriction was linked to lower IL-6 (β = −7.095, 95%CI: −11.286, −2.903) and IL-8 (β = −7.965, 95%CI: −14.700, −1.230) levels in women, but with higher IL-6 (β = 0.918, 95%CI: 0.161, 1.675) levels in men. Conclusions: Our findings support the association of adherence to the WCRF/AICR diet with gut microbiota and inflammation. These results need to be validated in additional prospective or interventional studies. MDPI 2023-08-24 /pmc/articles/PMC10490500/ /pubmed/37686736 http://dx.doi.org/10.3390/nu15173705 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Dan
Meng, Sijia
Li, Jiqiu
Zhao, Jing
Wang, Yu
Du, Meizhi
Wang, Yuan
Lu, Wenli
Zhu, Yun
Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title_full Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title_fullStr Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title_full_unstemmed Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title_short Associations of Adherence to the 2018 World Cancer Research Fund and the American Institute for Cancer Research Dietary Recommendations with Gut Microbiota and Inflammation Levels
title_sort associations of adherence to the 2018 world cancer research fund and the american institute for cancer research dietary recommendations with gut microbiota and inflammation levels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490500/
https://www.ncbi.nlm.nih.gov/pubmed/37686736
http://dx.doi.org/10.3390/nu15173705
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