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Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort

Accumulating evidence shows that NAFLD might play a role in the etiology and progression of CVD, but little is known on the association of NAFLD and CVD mortality in patients with a history of a myocardial infarction (MI). Therefore, we studied the relationship of Fatty Liver Index (FLI), as indicat...

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Autores principales: Heerkens, Luc, van Kleef, Laurens A., de Knegt, Robert J., Voortman, Trudy, Geleijnse, Johanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490853/
https://www.ncbi.nlm.nih.gov/pubmed/37682815
http://dx.doi.org/10.1371/journal.pone.0287467
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author Heerkens, Luc
van Kleef, Laurens A.
de Knegt, Robert J.
Voortman, Trudy
Geleijnse, Johanna M.
author_facet Heerkens, Luc
van Kleef, Laurens A.
de Knegt, Robert J.
Voortman, Trudy
Geleijnse, Johanna M.
author_sort Heerkens, Luc
collection PubMed
description Accumulating evidence shows that NAFLD might play a role in the etiology and progression of CVD, but little is known on the association of NAFLD and CVD mortality in patients with a history of a myocardial infarction (MI). Therefore, we studied the relationship of Fatty Liver Index (FLI), as indicator for non-alcoholic fatty liver disease (NAFLD), with 12-year risk of cardiovascular disease (CVD) and all-cause mortality in post-MI patients. We included 4165 Dutch patients from the Alpha Omega Cohort aged 60–80 years who had an MI ≤10 years prior to study enrolment. NAFLD was defined as FLI ≥60. Patients were followed for cause-specific mortality from enrolment (2002–2006) through December 2018. Hazard ratios for CVD and all-cause mortality were obtained by multivariable Cox regression using FLI <30 (indicating absence of NAFLD) as the reference. Baseline FLI as a continuous measure was studied with mortality using restricted cubic splines analyses. The median (IQR) FLI was 68 (48–84). Sixty percent of the patients had FLI ≥60, who were more likely to be male and more often had diabetes, high blood pressure, and high serum cholesterol levels. During 12 years of follow-up, 2042 deaths occurred of which 846 from CVD. Patients with NAFLD were at increased risk of CVD mortality (HR: 1.55 [1.19, 2.03]) and all-cause mortality (HR: 1.21 [1.03; 1.41]) compared to patients without NAFLD. Results remained consistent after excluding patients with obesity and diabetes. To conclude, the adverse association of FLI with CVD mortality was stronger in female than in male patients with conventional cut-off points. FLI ≥60, indicating NAFLD, was a predictor for CVD and all-cause mortality in post-MI patients, independent of other cardiometabolic risk factors. However, cut-off points might differ between male and female patients for predicting CVD mortality.
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spelling pubmed-104908532023-09-09 Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort Heerkens, Luc van Kleef, Laurens A. de Knegt, Robert J. Voortman, Trudy Geleijnse, Johanna M. PLoS One Research Article Accumulating evidence shows that NAFLD might play a role in the etiology and progression of CVD, but little is known on the association of NAFLD and CVD mortality in patients with a history of a myocardial infarction (MI). Therefore, we studied the relationship of Fatty Liver Index (FLI), as indicator for non-alcoholic fatty liver disease (NAFLD), with 12-year risk of cardiovascular disease (CVD) and all-cause mortality in post-MI patients. We included 4165 Dutch patients from the Alpha Omega Cohort aged 60–80 years who had an MI ≤10 years prior to study enrolment. NAFLD was defined as FLI ≥60. Patients were followed for cause-specific mortality from enrolment (2002–2006) through December 2018. Hazard ratios for CVD and all-cause mortality were obtained by multivariable Cox regression using FLI <30 (indicating absence of NAFLD) as the reference. Baseline FLI as a continuous measure was studied with mortality using restricted cubic splines analyses. The median (IQR) FLI was 68 (48–84). Sixty percent of the patients had FLI ≥60, who were more likely to be male and more often had diabetes, high blood pressure, and high serum cholesterol levels. During 12 years of follow-up, 2042 deaths occurred of which 846 from CVD. Patients with NAFLD were at increased risk of CVD mortality (HR: 1.55 [1.19, 2.03]) and all-cause mortality (HR: 1.21 [1.03; 1.41]) compared to patients without NAFLD. Results remained consistent after excluding patients with obesity and diabetes. To conclude, the adverse association of FLI with CVD mortality was stronger in female than in male patients with conventional cut-off points. FLI ≥60, indicating NAFLD, was a predictor for CVD and all-cause mortality in post-MI patients, independent of other cardiometabolic risk factors. However, cut-off points might differ between male and female patients for predicting CVD mortality. Public Library of Science 2023-09-08 /pmc/articles/PMC10490853/ /pubmed/37682815 http://dx.doi.org/10.1371/journal.pone.0287467 Text en © 2023 Heerkens et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Heerkens, Luc
van Kleef, Laurens A.
de Knegt, Robert J.
Voortman, Trudy
Geleijnse, Johanna M.
Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title_full Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title_fullStr Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title_full_unstemmed Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title_short Fatty Liver Index and mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort
title_sort fatty liver index and mortality after myocardial infarction: a prospective analysis in the alpha omega cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10490853/
https://www.ncbi.nlm.nih.gov/pubmed/37682815
http://dx.doi.org/10.1371/journal.pone.0287467
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