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Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains
Aggregation of antibody light chain proteins is associated with the progressive disease light chain amyloidosis. Patient-derived amyloid fibrils are formed from light chain variable domain residues in non-native conformations, highlighting a requirement that light chains unfold from their native str...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491100/ https://www.ncbi.nlm.nih.gov/pubmed/37693524 http://dx.doi.org/10.1101/2023.08.28.555139 |