The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture

Mutations in the nuclear Lamin A/C gene (LMNA) cause diverse degenerative disorders, including malignant dilated cardiomyopathy in adults. A prevailing hypothesis postulates that LMNA mutations cause nuclear envelope ruptures that trigger pathogenic inflammatory signaling via the cGAS-STING cytosoli...

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Detalles Bibliográficos
Autores principales: En, Atsuki, Bogireddi, Hanumakumar, Thomas, Briana, Stutzman, Alexis, Ikegami, Sachie, LaForest, Brigitte, Almakki, Omar, Pytel, Peter, Moskowitz, Ivan P., Ikegami, Kohta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491116/
https://www.ncbi.nlm.nih.gov/pubmed/37693381
http://dx.doi.org/10.1101/2023.08.28.555134

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