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Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

The prion-like spread of protein aggregates is a leading hypothesis for the propagation of neurofibrillary lesions in the brain, including the spread of tau inclusions associated with Alzheimer’s disease. The mechanisms of cellular uptake of tau seeds and subsequent nucleated polymerization of cytos...

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Detalles Bibliográficos
Autores principales:	Rose, Kevin, Jepson, Tyler, Shukla, Sankalp, Maya-Romero, Alex, Kampmann, Martin, Xu, Ke, Hurley, James H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491128/ https://www.ncbi.nlm.nih.gov/pubmed/37693477 http://dx.doi.org/10.1101/2023.08.28.555157

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