Tumor-Specific CD8(+) T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes

Immunotherapy is now an integral aspect of cancer therapy. Strategies employing adoptive cell therapy (ACT) have seen the establishment of chimeric antigen receptor (CAR)-T cells using peripheral blood lymphocytes as well as tumor infiltrating lymphocytes (TILs) with significant clinical results. De...

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Detalles Bibliográficos
Autores principales: Zawidzka, Elizabeth M., Biavati, Luca, Thomas, Amy, Zanettini, Claudio, Marchionni, Luigi, Leone, Robert, Borrello, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491133/
https://www.ncbi.nlm.nih.gov/pubmed/37693379
http://dx.doi.org/10.1101/2023.08.28.555119

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