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LRMP inhibits the cAMP-dependence of HCN4 channels by disrupting intramolecular signal transduction

Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation in HCN4 but the interaction domains, mechanisms of action, and basis for isoform-specificity remain u...

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Detalles Bibliográficos
Autores principales:	Peters, Colin H, Singh, Rohit K, Langley, Avery A, Nichols, William G, Ferris, Hannah R, Jeffrey, Danielle A, Proenza, Catherine, Bankston, John R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491135/ https://www.ncbi.nlm.nih.gov/pubmed/37693562 http://dx.doi.org/10.1101/2023.08.29.555242

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