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Discovering optimal kinetic pathways for self-assembly using automatic differentiation

During self-assembly of macromolecules ranging from ribosomes to viral capsids, the formation of long-lived intermediates or kinetic traps can dramatically reduce yield of the functional products. Understanding biological mechanisms for avoiding traps and efficiently assembling is essential for desi...

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Detalles Bibliográficos
Autores principales: Jhaveri, Adip, Loggia, Spencer, Qian, Yian, Johnson, Margaret E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491160/
https://www.ncbi.nlm.nih.gov/pubmed/37693527
http://dx.doi.org/10.1101/2023.08.30.555551