Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection

Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in generating long-lived high affinity antibodies, t...

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Detalles Bibliográficos
Autores principales: Sircy, Linda M., Ramstead, Andrew G., Joshi, Hemant, Baessler, Andrew, Mena, Ignacio, García-Sastre, Adolfo, Williams, Matthew A., Scott Hale, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491174/
https://www.ncbi.nlm.nih.gov/pubmed/37693425
http://dx.doi.org/10.1101/2023.08.29.555253

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