DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of Medicine

Alzheimer’s Disease (AD) is the 6th leading cause of death in the US. It is established that neuroinflammation contributes to the synaptic loss, neuronal death, and symptomatic decline of AD patients. Accumulating evidence suggests a critical role for microglia, innate immune phagocytes of the brain...

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Detalles Bibliográficos
Autores principales: Daily, Kylene P., Badr, Asmaa, Eltobgy, Mostafa, Estfanous, Shady, Whitham, Owen, Tan, Michelle H., Carafice, Cierra, Krause, Kathrin, McNamara, Andrew, Hamilton, Kaitlin, Houle, Samuel, Gupta, Spandan, Gupta, Gauruv A., Madhu, Shruthi, Fitzgerald, Julie, Saadey, Abbey A., Laster, Brooke, Yan, Pearlly, Webb, Amy, Zhang, Xiaoli, Pietrzak, Maciej, Kokiko-Cochran, Olga N., Ghoneim, Hazem E., Amer, Amal O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491177/
https://www.ncbi.nlm.nih.gov/pubmed/37693600
http://dx.doi.org/10.1101/2023.08.30.555526

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