SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of PPM1D are found across sev...

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Detalles Bibliográficos
Autores principales: Zhang, Linda, Hsu, Joanne I., Braekeleer, Etienne D., Chen, Chun-Wei, Patel, Tajhal D., Urya, Hidetaka, Guzman, Anna G., Martell, Alejandra G., Waldvogel, Sarah M., Tovy, Ayala, Callen, Elsa, Murdaugh, Rebecca, Richard, Rosemary, Jansen, Sandra, Vissers, Lisenka, de Vries, Bert B.A., Nussenzweig, Andre, Huang, Shixia, Coarfa, Cristian, Anastas, Jamie N., Takahashi, Koichi, Vassiliou, George, Goodell, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491179/
https://www.ncbi.nlm.nih.gov/pubmed/37693622
http://dx.doi.org/10.1101/2023.08.31.555634

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