A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant(1-3). AT2 dysfunction underlies many lung diseases including interstitial lung disease (ILD), in which some inherited forms result from mislocalisation of surfactant protein C (SFTPC) variants...

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Detalles Bibliográficos
Autores principales: Lim, Kyungtae, Rutherford, Eimear N., Sun, Dawei, Van den Boomen, Dick J. H., Edgar, James R., Bang, Jae Hak, Matesic, Lydia E., Lee, Joo-Hyeon, Lehner, Paul J., Marciniak, Stefan J., Rawlins, Emma L., Dickens, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491189/
https://www.ncbi.nlm.nih.gov/pubmed/37693487
http://dx.doi.org/10.1101/2023.08.30.555522

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