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Oxidative regulation of TDP-43 self-association by a β-to-α conformational switch

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An evolutionarily conserved region of the TDP-43 low complexity domain twenty residues in length can adopt either an α-helical or β-strand conformation. When in the latter conformation, TDP-43 self-associates via the formation of a labile, cross-β structure. Self-association can be monitored via the...

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Detalles Bibliográficos
Autores principales:	Gu, Jinge, Zhou, Xiaoming, Sutherland, Lillian, Kato, Masato, Jaczynska, Klaudia, Rizo, Josep, McKnight, Steven L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491227/ https://www.ncbi.nlm.nih.gov/pubmed/37693418 http://dx.doi.org/10.1101/2023.08.29.555361

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