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Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop

Although the αC-β4 loop is a stable feature of all protein kinases, the importance of this motif as a conserved element of secondary structure, as well as its links to the hydrophobic architecture of the kinase core, has been underappreciated. We first review the motif and then describe how it is li...

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Detalles Bibliográficos
Autores principales: Wu, Jian, Jonniya, Nisha A., Hirakis, Sophia P., Olivieri, Cristina, Veglia, Gianluigi, Kornev, Alexandr P., Taylor, Susan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491255/
https://www.ncbi.nlm.nih.gov/pubmed/37693538
http://dx.doi.org/10.1101/2023.08.31.555822