Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells

Angelman Syndrome (AS) and Prader-Willi Syndrome (PWS), two distinct neurodevelopmental disorders, result from loss of expression from imprinted genes in the chromosome 15q11-13 locus most commonly caused by a megabase-scale deletion on either the maternal or paternal allele, respectively. Each occu...

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Detalles Bibliográficos
Autores principales: Gilmore, Rachel B., Gorka, Dea, Stoddard, Christopher E., Cotney, Justin L., Chamberlain, Stormy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491257/
https://www.ncbi.nlm.nih.gov/pubmed/37693591
http://dx.doi.org/10.1101/2023.08.30.555563

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