Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke

The stability of tight junctions (TJs) between endothelial cells (ECs) is essential to maintain blood-brain barrier (BBB) function in the healthy brain. Following ischemic stroke, TJ strand dismantlement due to protein degradation leads to BBB dysfunction, yet the mechanisms driving this process are...

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Detalles Bibliográficos
Autores principales: Cottarelli, Azzurra, Shahriar, Sanjid, Arac, Ahmet, Glendinning, Michael, Tuohy, Mary Claire, Prochilo, Grace, Neal, Jason B., Edinger, Aimee L., Agalliu, Dritan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491261/
https://www.ncbi.nlm.nih.gov/pubmed/37693406
http://dx.doi.org/10.1101/2023.08.29.555373

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