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The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database
OBJECTIVE: To develop a harmonized multicenter clinical and electroencephalography (EEG) database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest. DESIGN: Multicenter cohort, partly prospective and partly retrospective. SETTING: Seven academic or teaching hosp...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491275/ https://www.ncbi.nlm.nih.gov/pubmed/37693458 http://dx.doi.org/10.1101/2023.08.28.23294672 |
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author | Amorim, Edilberto Zheng, Wei-Long Ghassemi, Mohammad M. Aghaeeaval, Mahsa Kandhare, Pravinkumar Karukonda, Vishnu Lee, Jong Woo Herman, Susan T. Sivaraju, Adithya Gaspard, Nicolas Hofmeijer, Jeannette van Putten, Michel J. A. M. Sameni, Reza Reyna, Matthew A. Clifford, Gari D. Westover, M. Brandon |
author_facet | Amorim, Edilberto Zheng, Wei-Long Ghassemi, Mohammad M. Aghaeeaval, Mahsa Kandhare, Pravinkumar Karukonda, Vishnu Lee, Jong Woo Herman, Susan T. Sivaraju, Adithya Gaspard, Nicolas Hofmeijer, Jeannette van Putten, Michel J. A. M. Sameni, Reza Reyna, Matthew A. Clifford, Gari D. Westover, M. Brandon |
author_sort | Amorim, Edilberto |
collection | PubMed |
description | OBJECTIVE: To develop a harmonized multicenter clinical and electroencephalography (EEG) database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest. DESIGN: Multicenter cohort, partly prospective and partly retrospective. SETTING: Seven academic or teaching hospitals from the U.S. and Europe. PATIENTS: Individuals aged 16 or older who were comatose after return of spontaneous circulation following a cardiac arrest who had continuous EEG monitoring were included. INTERVENTIONS: not applicable. MEASUREMENTS AND MAIN RESULTS: Clinical and EEG data were harmonized and stored in a common Waveform Database (WFDB)-compatible format. Automated spike frequency, background continuity, and artifact detection on EEG were calculated with 10 second resolution and summarized hourly. Neurological outcome was determined at 3–6 months using the best Cerebral Performance Category (CPC) scale. This database includes clinical and 56,676 hours (3.9 TB) of continuous EEG data for 1,020 patients. Most patients died (N=603, 59%), 48 (5%) had severe neurological disability (CPC 3 or 4), and 369 (36%) had good functional recovery (CPC 1–2). There is significant variability in mean EEG recording duration depending on the neurological outcome (range 53–102h for CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in frequency for at least one hour was seen in 258 (25%) patients (19% for CPC 1–2 and 29% for CPC 3–5). Burst suppression was observed for at least one hour in 207 (56%) and 635 (97%) patients with CPC 1–2 and CPC 3–5, respectively. CONCLUSIONS: The International Cardiac Arrest Research (I-CARE) consortium database provides a comprehensive real-world clinical and EEG dataset for neurophysiology research of comatose patients after cardiac arrest. This dataset covers the spectrum of abnormal EEG patterns after cardiac arrest, including epileptiform patterns and those in the ictal-interictal continuum. |
format | Online Article Text |
id | pubmed-10491275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-104912752023-09-09 The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database Amorim, Edilberto Zheng, Wei-Long Ghassemi, Mohammad M. Aghaeeaval, Mahsa Kandhare, Pravinkumar Karukonda, Vishnu Lee, Jong Woo Herman, Susan T. Sivaraju, Adithya Gaspard, Nicolas Hofmeijer, Jeannette van Putten, Michel J. A. M. Sameni, Reza Reyna, Matthew A. Clifford, Gari D. Westover, M. Brandon medRxiv Article OBJECTIVE: To develop a harmonized multicenter clinical and electroencephalography (EEG) database for acute hypoxic-ischemic brain injury research involving patients with cardiac arrest. DESIGN: Multicenter cohort, partly prospective and partly retrospective. SETTING: Seven academic or teaching hospitals from the U.S. and Europe. PATIENTS: Individuals aged 16 or older who were comatose after return of spontaneous circulation following a cardiac arrest who had continuous EEG monitoring were included. INTERVENTIONS: not applicable. MEASUREMENTS AND MAIN RESULTS: Clinical and EEG data were harmonized and stored in a common Waveform Database (WFDB)-compatible format. Automated spike frequency, background continuity, and artifact detection on EEG were calculated with 10 second resolution and summarized hourly. Neurological outcome was determined at 3–6 months using the best Cerebral Performance Category (CPC) scale. This database includes clinical and 56,676 hours (3.9 TB) of continuous EEG data for 1,020 patients. Most patients died (N=603, 59%), 48 (5%) had severe neurological disability (CPC 3 or 4), and 369 (36%) had good functional recovery (CPC 1–2). There is significant variability in mean EEG recording duration depending on the neurological outcome (range 53–102h for CPC 1 and CPC 4, respectively). Epileptiform activity averaging 1 Hz or more in frequency for at least one hour was seen in 258 (25%) patients (19% for CPC 1–2 and 29% for CPC 3–5). Burst suppression was observed for at least one hour in 207 (56%) and 635 (97%) patients with CPC 1–2 and CPC 3–5, respectively. CONCLUSIONS: The International Cardiac Arrest Research (I-CARE) consortium database provides a comprehensive real-world clinical and EEG dataset for neurophysiology research of comatose patients after cardiac arrest. This dataset covers the spectrum of abnormal EEG patterns after cardiac arrest, including epileptiform patterns and those in the ictal-interictal continuum. Cold Spring Harbor Laboratory 2023-08-28 /pmc/articles/PMC10491275/ /pubmed/37693458 http://dx.doi.org/10.1101/2023.08.28.23294672 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Amorim, Edilberto Zheng, Wei-Long Ghassemi, Mohammad M. Aghaeeaval, Mahsa Kandhare, Pravinkumar Karukonda, Vishnu Lee, Jong Woo Herman, Susan T. Sivaraju, Adithya Gaspard, Nicolas Hofmeijer, Jeannette van Putten, Michel J. A. M. Sameni, Reza Reyna, Matthew A. Clifford, Gari D. Westover, M. Brandon The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title | The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title_full | The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title_fullStr | The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title_full_unstemmed | The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title_short | The International Cardiac Arrest Research (I-CARE) Consortium Electroencephalography Database |
title_sort | international cardiac arrest research (i-care) consortium electroencephalography database |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491275/ https://www.ncbi.nlm.nih.gov/pubmed/37693458 http://dx.doi.org/10.1101/2023.08.28.23294672 |
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