Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis

Tropomyosins coat actin filaments and impact actin-related signaling and cell morphogenesis. Genome-wide association studies have linked Tropomyosin 1 (TPM1) with human blood trait variation. Prior work suggested that TPM1 regulated blood cell formation in vitro, but it was unclear how or when TPM1...

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Detalles Bibliográficos
Autores principales: Wilken, Madison B, Fonar, Gennadiy, Nations, Catriana, Pavani, Giulia, Tsao, Victor, Garifallou, James, Tober, Joanna, Bennett, Laura, Maguire, Jean Ann, Gagne, Alyssa, Okoli, Nkemdilim, Gadue, Paul, Chou, Stella T, Speck, Nancy A, French, Deborah L, Thom, Christopher S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491315/
https://www.ncbi.nlm.nih.gov/pubmed/37693628
http://dx.doi.org/10.1101/2023.09.01.555861

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