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Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels

This paper aims to examine the ability to control Red Blood Cell (RBCs) dynamics and the associated extracellular flow patterns in microfluidic channels via oscillatory flows. Our computational approach employs a hybrid continuum-particle coupling, in which the cell membrane and cytosol fluid are mo...

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Autores principales: Akerkouch, Lahcen, Le, Trung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491371/
https://www.ncbi.nlm.nih.gov/pubmed/37693621
http://dx.doi.org/10.21203/rs.3.rs-3296659/v1
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author Akerkouch, Lahcen
Le, Trung
author_facet Akerkouch, Lahcen
Le, Trung
author_sort Akerkouch, Lahcen
collection PubMed
description This paper aims to examine the ability to control Red Blood Cell (RBCs) dynamics and the associated extracellular flow patterns in microfluidic channels via oscillatory flows. Our computational approach employs a hybrid continuum-particle coupling, in which the cell membrane and cytosol fluid are modeled using the Dissipative Particle Dynamics (DPD) method. The blood plasma is modeled as an incompressible fluid via the Immersed Boundary Method (IBM). This coupling is novel because it provides an accurate description of RBC dynamics while the extracellular flow patterns around the RBCs are also captured in detail. Our coupling methodology is validated with available experimental and computational data in the literature and shows excellent agreement. We explore the controlling regimes by varying the shape of the oscillatory flow waveform at the channel inlet. Our simulation results show that a host of RBC morphological dynamics emerges depending on the channel geometry, the incoming flow waveform, and the RBC initial location. Complex dynamics of RBC are induced by the flow waveform. Our results show that the RBC shape is strongly dependent on its initial location. Our results suggest that the controlling of oscillatory flows can be used to induce specific morphological shapes of RBCs and the surrounding fluid patterns in bio-engineering applications.
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spelling pubmed-104913712023-09-09 Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels Akerkouch, Lahcen Le, Trung Res Sq Article This paper aims to examine the ability to control Red Blood Cell (RBCs) dynamics and the associated extracellular flow patterns in microfluidic channels via oscillatory flows. Our computational approach employs a hybrid continuum-particle coupling, in which the cell membrane and cytosol fluid are modeled using the Dissipative Particle Dynamics (DPD) method. The blood plasma is modeled as an incompressible fluid via the Immersed Boundary Method (IBM). This coupling is novel because it provides an accurate description of RBC dynamics while the extracellular flow patterns around the RBCs are also captured in detail. Our coupling methodology is validated with available experimental and computational data in the literature and shows excellent agreement. We explore the controlling regimes by varying the shape of the oscillatory flow waveform at the channel inlet. Our simulation results show that a host of RBC morphological dynamics emerges depending on the channel geometry, the incoming flow waveform, and the RBC initial location. Complex dynamics of RBC are induced by the flow waveform. Our results show that the RBC shape is strongly dependent on its initial location. Our results suggest that the controlling of oscillatory flows can be used to induce specific morphological shapes of RBCs and the surrounding fluid patterns in bio-engineering applications. American Journal Experts 2023-08-30 /pmc/articles/PMC10491371/ /pubmed/37693621 http://dx.doi.org/10.21203/rs.3.rs-3296659/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Akerkouch, Lahcen
Le, Trung
Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title_full Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title_fullStr Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title_full_unstemmed Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title_short Shape Transitions of Red Blood Cell under Oscillatory Flows in Microchannels
title_sort shape transitions of red blood cell under oscillatory flows in microchannels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491371/
https://www.ncbi.nlm.nih.gov/pubmed/37693621
http://dx.doi.org/10.21203/rs.3.rs-3296659/v1
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