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The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy

Objective  To evaluate the fetal and maternal effects of the severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection in women with hypertensive disorders of pregnancy. Methods  Patients with hypertensive disorders of pregnancy and SARS-CoV-2 polymerase chain reaction (PCR) positivity ( n  =...

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Autores principales: Farisoğulları, Nihat, Denizli, Ramazan, Sakcak, Bedri, Tanaçan, Atakan, Kara, Özgür, Şahin, Dilek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Revinter Publicações Ltda. 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491470/
https://www.ncbi.nlm.nih.gov/pubmed/37683655
http://dx.doi.org/10.1055/s-0043-1772184
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author Farisoğulları, Nihat
Denizli, Ramazan
Sakcak, Bedri
Tanaçan, Atakan
Kara, Özgür
Şahin, Dilek
author_facet Farisoğulları, Nihat
Denizli, Ramazan
Sakcak, Bedri
Tanaçan, Atakan
Kara, Özgür
Şahin, Dilek
author_sort Farisoğulları, Nihat
collection PubMed
description Objective  To evaluate the fetal and maternal effects of the severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection in women with hypertensive disorders of pregnancy. Methods  Patients with hypertensive disorders of pregnancy and SARS-CoV-2 polymerase chain reaction (PCR) positivity ( n  = 55) were compared with cases with similar characteristics and PCR negativity ( n  = 53). The study group was further divided into two groups as severe ( n  = 11) and nonsevere ( n  = 44) coronavirus disease 2019 (COVID-19). The groups were compared in terms of clinical characteristics and perinatal outcomes. Results  The study and control groups were similar in terms of maternal age, parity, gestational age at diagnosis, type of hypertensive disorders, magnesium sulfate administration rate, gestational age at birth, birth weight, Apgar scores, and maternal complications. However, all cases of fetal loss ( n  = 6) were observed in the SARS-CoV-2 positive group ( p  = 0.027). From the 6 cases, there were 5 in the nonsevere group and 1 patient in the severe SARS-CoV-2 positive group. Moreover, higher rates of maternal complications, lower oxygen saturation values, and intensive care unit admissions were observed in the severe COVID-19 group. Conclusion  Physicians should be cautious about the management of hypertensive disorders of pregnancy cases with SARS-CoV-2 positivity. Fetal loss seems to be more common in cases with SARS-CoV-2 positivity and severe COVID-19 seems to be associated with higher rates of maternal complications. Close follow-up for fetal wellbeing and active management of severe cases in terms of maternal complications seem to be favorable.
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spelling pubmed-104914702023-09-09 The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy Farisoğulları, Nihat Denizli, Ramazan Sakcak, Bedri Tanaçan, Atakan Kara, Özgür Şahin, Dilek Rev Bras Ginecol Obstet Objective  To evaluate the fetal and maternal effects of the severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection in women with hypertensive disorders of pregnancy. Methods  Patients with hypertensive disorders of pregnancy and SARS-CoV-2 polymerase chain reaction (PCR) positivity ( n  = 55) were compared with cases with similar characteristics and PCR negativity ( n  = 53). The study group was further divided into two groups as severe ( n  = 11) and nonsevere ( n  = 44) coronavirus disease 2019 (COVID-19). The groups were compared in terms of clinical characteristics and perinatal outcomes. Results  The study and control groups were similar in terms of maternal age, parity, gestational age at diagnosis, type of hypertensive disorders, magnesium sulfate administration rate, gestational age at birth, birth weight, Apgar scores, and maternal complications. However, all cases of fetal loss ( n  = 6) were observed in the SARS-CoV-2 positive group ( p  = 0.027). From the 6 cases, there were 5 in the nonsevere group and 1 patient in the severe SARS-CoV-2 positive group. Moreover, higher rates of maternal complications, lower oxygen saturation values, and intensive care unit admissions were observed in the severe COVID-19 group. Conclusion  Physicians should be cautious about the management of hypertensive disorders of pregnancy cases with SARS-CoV-2 positivity. Fetal loss seems to be more common in cases with SARS-CoV-2 positivity and severe COVID-19 seems to be associated with higher rates of maternal complications. Close follow-up for fetal wellbeing and active management of severe cases in terms of maternal complications seem to be favorable. Thieme Revinter Publicações Ltda. 2023-09-08 /pmc/articles/PMC10491470/ /pubmed/37683655 http://dx.doi.org/10.1055/s-0043-1772184 Text en Federação Brasileira de Ginecologia e Obstetrícia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Farisoğulları, Nihat
Denizli, Ramazan
Sakcak, Bedri
Tanaçan, Atakan
Kara, Özgür
Şahin, Dilek
The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title_full The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title_fullStr The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title_full_unstemmed The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title_short The Effect of SARS-CoV-2 İnfection on Perinatal Outcomes in Hypertensive Disorders of Pregnancy
title_sort effect of sars-cov-2 i̇nfection on perinatal outcomes in hypertensive disorders of pregnancy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491470/
https://www.ncbi.nlm.nih.gov/pubmed/37683655
http://dx.doi.org/10.1055/s-0043-1772184
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