The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination

XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudoautosomal region (PAR), a defect that may occur in mi...

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Detalles Bibliográficos
Autores principales: Giannattasio, Teresa, Testa, Erika, Faieta, Monica, Lampitto, Matteo, Nardozi, Daniela, di Cecca, Stefano, Russo, Antonella, Barchi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491539/
https://www.ncbi.nlm.nih.gov/pubmed/37682311
http://dx.doi.org/10.1007/s00018-023-04912-7

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