Randomized phase-III study of low-dose cytarabine and etoposide + /− all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia

The aim of this randomized clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with non-intensive chemotherapy in older unfit patients (> 60 years) with newly diagnosed NPM1-mutated acute myeloid leukemia. Patients were randomized (1:1) to low-dose chemother...

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Detalles Bibliográficos
Autores principales: Schlenk, R. F., Weber, D., Krzykalla, J., Kindler, T., Wulf, G., Hertenstein, B., Salih, H. R., Südhoff, T., Krauter, J., Martens, U., Wessendorf, S., Runde, V., Tischler, H. J., Bentz, M., Koller, E., Heuser, M., Thol, F., Benner, A., Ganser, A., Döhner, K., Döhner, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491626/
https://www.ncbi.nlm.nih.gov/pubmed/37684299
http://dx.doi.org/10.1038/s41598-023-41964-y

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