Valproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase

Inositol depletion is a hypothesized mechanism of action of mood stabilization drugs used in the treatment of bipolar disorder. It was previously reported that the mood stabilizer valproate (VPA) increased phosphorylation of myo-inositol-3-phosphate synthases (MIPS), the rate limiting enzyme of inos...

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Detalles Bibliográficos
Autores principales: Case, Kendall C., Beltman, Rachel J., Pflum, Mary Kay H., Greenberg, Miriam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491628/
https://www.ncbi.nlm.nih.gov/pubmed/37684289
http://dx.doi.org/10.1038/s41598-023-41936-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491628/
https://www.ncbi.nlm.nih.gov/pubmed/37684289
http://dx.doi.org/10.1038/s41598-023-41936-2

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