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Predictors of lower exercise capacity in patients with cancer
Maintaining cancer patients’ exercise capacity and therefore patients’ ability to live a self-determined life is of huge importance, but little is known about major determinants. We sought to identify determinants of exercise capacity in patients with a broad spectrum of cancer types, who were alrea...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491652/ https://www.ncbi.nlm.nih.gov/pubmed/37684302 http://dx.doi.org/10.1038/s41598-023-41390-0 |
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author | Evertz, Ruben Diehl, Christine Gödde, Katharina Valentova, Miroslava Garfias-Veitl, Tania Overbeck, Tobias R. Braulke, Friederike Lena, Alessia Hadzibegovic, Sara Bleckmann, Annalen Keller, Ulrich Landmesser, Ulf König, Alexander O. Hasenfuss, Gerd Schuster, Andreas Anker, Markus S. von Haehling, Stephan |
author_facet | Evertz, Ruben Diehl, Christine Gödde, Katharina Valentova, Miroslava Garfias-Veitl, Tania Overbeck, Tobias R. Braulke, Friederike Lena, Alessia Hadzibegovic, Sara Bleckmann, Annalen Keller, Ulrich Landmesser, Ulf König, Alexander O. Hasenfuss, Gerd Schuster, Andreas Anker, Markus S. von Haehling, Stephan |
author_sort | Evertz, Ruben |
collection | PubMed |
description | Maintaining cancer patients’ exercise capacity and therefore patients’ ability to live a self-determined life is of huge importance, but little is known about major determinants. We sought to identify determinants of exercise capacity in patients with a broad spectrum of cancer types, who were already receiving cancer treatment or about to commence such therapy. Exercise capacity was assessed in 253 consecutive patients mostly suffering from advanced cancer using the 6-min walk test (6-MWT). All patients underwent echocardiography, physical examination, resting electrocardiogram, hand grip strength (HGS) measurement, and laboratory assessments. Patients were divided into two groups according to the median distance in the 6-MWT (459 m). Patients with lower exercise capacity were older, had significantly lower HGS and haemoglobin and higher values of high sensitive (hs) Troponin T and NT-proBNP (all p < 0.05). Whilst the co-morbidity burden was significantly higher in this group, no differences were detected for sex, body mass index, tumor type, or cachexia (all p > 0.2). Using multivariable logistic regression, we found that the presence of anaemia (odds ratio (OR) 6.172, 95% confidence interval (CI) 1.401–27.201, p = 0.016) as well as an increase in hs Troponin T (OR 3.077, 95% CI 1.202–5.301, p = 0.019) remained independent predictors of impaired exercise capacity. Increasing HGS was associated with a reduced risk of a lower exercise capacity (OR 0.896, 95% CI 0.813–0.987, p = 0.026). Screening patients for elevated hs troponin levels as well as reduced HGS may help to identify patients at risk of lower exercise capacity during cancer treatment. |
format | Online Article Text |
id | pubmed-10491652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104916522023-09-10 Predictors of lower exercise capacity in patients with cancer Evertz, Ruben Diehl, Christine Gödde, Katharina Valentova, Miroslava Garfias-Veitl, Tania Overbeck, Tobias R. Braulke, Friederike Lena, Alessia Hadzibegovic, Sara Bleckmann, Annalen Keller, Ulrich Landmesser, Ulf König, Alexander O. Hasenfuss, Gerd Schuster, Andreas Anker, Markus S. von Haehling, Stephan Sci Rep Article Maintaining cancer patients’ exercise capacity and therefore patients’ ability to live a self-determined life is of huge importance, but little is known about major determinants. We sought to identify determinants of exercise capacity in patients with a broad spectrum of cancer types, who were already receiving cancer treatment or about to commence such therapy. Exercise capacity was assessed in 253 consecutive patients mostly suffering from advanced cancer using the 6-min walk test (6-MWT). All patients underwent echocardiography, physical examination, resting electrocardiogram, hand grip strength (HGS) measurement, and laboratory assessments. Patients were divided into two groups according to the median distance in the 6-MWT (459 m). Patients with lower exercise capacity were older, had significantly lower HGS and haemoglobin and higher values of high sensitive (hs) Troponin T and NT-proBNP (all p < 0.05). Whilst the co-morbidity burden was significantly higher in this group, no differences were detected for sex, body mass index, tumor type, or cachexia (all p > 0.2). Using multivariable logistic regression, we found that the presence of anaemia (odds ratio (OR) 6.172, 95% confidence interval (CI) 1.401–27.201, p = 0.016) as well as an increase in hs Troponin T (OR 3.077, 95% CI 1.202–5.301, p = 0.019) remained independent predictors of impaired exercise capacity. Increasing HGS was associated with a reduced risk of a lower exercise capacity (OR 0.896, 95% CI 0.813–0.987, p = 0.026). Screening patients for elevated hs troponin levels as well as reduced HGS may help to identify patients at risk of lower exercise capacity during cancer treatment. Nature Publishing Group UK 2023-09-08 /pmc/articles/PMC10491652/ /pubmed/37684302 http://dx.doi.org/10.1038/s41598-023-41390-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Evertz, Ruben Diehl, Christine Gödde, Katharina Valentova, Miroslava Garfias-Veitl, Tania Overbeck, Tobias R. Braulke, Friederike Lena, Alessia Hadzibegovic, Sara Bleckmann, Annalen Keller, Ulrich Landmesser, Ulf König, Alexander O. Hasenfuss, Gerd Schuster, Andreas Anker, Markus S. von Haehling, Stephan Predictors of lower exercise capacity in patients with cancer |
title | Predictors of lower exercise capacity in patients with cancer |
title_full | Predictors of lower exercise capacity in patients with cancer |
title_fullStr | Predictors of lower exercise capacity in patients with cancer |
title_full_unstemmed | Predictors of lower exercise capacity in patients with cancer |
title_short | Predictors of lower exercise capacity in patients with cancer |
title_sort | predictors of lower exercise capacity in patients with cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491652/ https://www.ncbi.nlm.nih.gov/pubmed/37684302 http://dx.doi.org/10.1038/s41598-023-41390-0 |
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