Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities

In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity...

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Detalles Bibliográficos
Autores principales: Machado, Nicole D., Heather, Lisa C., Harris, Adrian L., Higgins, Geoff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491675/
https://www.ncbi.nlm.nih.gov/pubmed/37563220
http://dx.doi.org/10.1038/s41416-023-02394-9
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author Machado, Nicole D.
Heather, Lisa C.
Harris, Adrian L.
Higgins, Geoff S.
author_facet Machado, Nicole D.
Heather, Lisa C.
Harris, Adrian L.
Higgins, Geoff S.
author_sort Machado, Nicole D.
collection PubMed
description In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie.
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spelling pubmed-104916752023-09-10 Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities Machado, Nicole D. Heather, Lisa C. Harris, Adrian L. Higgins, Geoff S. Br J Cancer Comment In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity and toxicity demonstrate what lessons can be learned from this failure and where new opportunities lie. Nature Publishing Group UK 2023-08-10 2023-10-05 /pmc/articles/PMC10491675/ /pubmed/37563220 http://dx.doi.org/10.1038/s41416-023-02394-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Machado, Nicole D.
Heather, Lisa C.
Harris, Adrian L.
Higgins, Geoff S.
Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title_full Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title_fullStr Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title_full_unstemmed Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title_short Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
title_sort targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491675/
https://www.ncbi.nlm.nih.gov/pubmed/37563220
http://dx.doi.org/10.1038/s41416-023-02394-9
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