Cargando…

Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities

In light of the disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies has been called into question. Consideration of these agents’ potency, tissue selectivity...

Descripción completa

Detalles Bibliográficos
Autores principales: Machado, Nicole D., Heather, Lisa C., Harris, Adrian L., Higgins, Geoff S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491675/
https://www.ncbi.nlm.nih.gov/pubmed/37563220
http://dx.doi.org/10.1038/s41416-023-02394-9