Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature

KEY CLINICAL MESSAGE: This case report supports that trauma can rarely cause thrombotic microangiopathy (TMA). Early recognition is important due to a high mortality of untreated TMA, but diagnosis can be delayed by attributing lab abnormalities as due to blood loss. ABSTRACT: Major trauma can provo...

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Autores principales: Van Meerbeeck, Xavier, Janssen, Leen, Vleut, Rowena, Verdonck, Philip, Gadisseur, Alain, De Paep, Rudi, Verbrugghe, Walter, Jorens, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491750/
https://www.ncbi.nlm.nih.gov/pubmed/37692157
http://dx.doi.org/10.1002/ccr3.7838
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author Van Meerbeeck, Xavier
Janssen, Leen
Vleut, Rowena
Verdonck, Philip
Gadisseur, Alain
De Paep, Rudi
Verbrugghe, Walter
Jorens, Philippe
author_facet Van Meerbeeck, Xavier
Janssen, Leen
Vleut, Rowena
Verdonck, Philip
Gadisseur, Alain
De Paep, Rudi
Verbrugghe, Walter
Jorens, Philippe
author_sort Van Meerbeeck, Xavier
collection PubMed
description KEY CLINICAL MESSAGE: This case report supports that trauma can rarely cause thrombotic microangiopathy (TMA). Early recognition is important due to a high mortality of untreated TMA, but diagnosis can be delayed by attributing lab abnormalities as due to blood loss. ABSTRACT: Major trauma can provoke coagulopathy, ranging from hypo‐ to hypercoagulation. Thrombotic microangiopathy (TMA), characterized by hemolytic anemia, renal failure, thrombocytopenia, and intravascular hemolysis, results in bleeding tendency but also microvascular thrombosis. We report a rare case of isolated traumatic brain injury leading to TMA treated with plasmapheresis.
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spelling pubmed-104917502023-09-10 Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature Van Meerbeeck, Xavier Janssen, Leen Vleut, Rowena Verdonck, Philip Gadisseur, Alain De Paep, Rudi Verbrugghe, Walter Jorens, Philippe Clin Case Rep Case Report KEY CLINICAL MESSAGE: This case report supports that trauma can rarely cause thrombotic microangiopathy (TMA). Early recognition is important due to a high mortality of untreated TMA, but diagnosis can be delayed by attributing lab abnormalities as due to blood loss. ABSTRACT: Major trauma can provoke coagulopathy, ranging from hypo‐ to hypercoagulation. Thrombotic microangiopathy (TMA), characterized by hemolytic anemia, renal failure, thrombocytopenia, and intravascular hemolysis, results in bleeding tendency but also microvascular thrombosis. We report a rare case of isolated traumatic brain injury leading to TMA treated with plasmapheresis. John Wiley and Sons Inc. 2023-09-08 /pmc/articles/PMC10491750/ /pubmed/37692157 http://dx.doi.org/10.1002/ccr3.7838 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Van Meerbeeck, Xavier
Janssen, Leen
Vleut, Rowena
Verdonck, Philip
Gadisseur, Alain
De Paep, Rudi
Verbrugghe, Walter
Jorens, Philippe
Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title_full Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title_fullStr Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title_full_unstemmed Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title_short Thrombotic microangiopathy after traumatic brain injury: A case report and review of the literature
title_sort thrombotic microangiopathy after traumatic brain injury: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491750/
https://www.ncbi.nlm.nih.gov/pubmed/37692157
http://dx.doi.org/10.1002/ccr3.7838
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