Simplifying glycan monitoring of complex antigens such as the SARS-CoV-2 spike to accelerate vaccine development

Glycosylation is a key quality attribute that must be closely monitored for protein therapeutics. Established assays such as HILIC-Fld of released glycans and LC-MS of glycopeptides work well for glycoproteins with a few glycosylation sites but are less amenable for those with multiple glycosylation...

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Detalles Bibliográficos
Autores principales: Sauvageau, Janelle, Koyuturk, Izel, St. Michael, Frank, Brochu, Denis, Goneau, Marie-France, Schoenhofen, Ian, Perret, Sylvie, Star, Alexandra, Robotham, Anna, Haqqani, Arsalan, Kelly, John, Gilbert, Michel, Durocher, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491790/
https://www.ncbi.nlm.nih.gov/pubmed/37684364
http://dx.doi.org/10.1038/s42004-023-00988-1

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