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Development of an in vitro genotoxicity assay to detect retroviral vector-induced lymphoid insertional mutants

Safety assessment in retroviral vector-mediated gene therapy remains challenging. In clinical trials for different blood and immune disorders, insertional mutagenesis led to myeloid and lymphoid leukemia. We previously developed the In Vitro Immortalization Assay (IVIM) and Surrogate Assay for Genot...

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Detalles Bibliográficos
Autores principales:	Bastone, Antonella L., Dziadek, Violetta, John-Neek, Philipp, Mansel, Friederike, Fleischauer, Jenni, Agyeman-Duah, Eric, Schaudien, Dirk, Dittrich-Breiholz, Oliver, Schwarzer, Adrian, Schambach, Axel, Rothe, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491817/ https://www.ncbi.nlm.nih.gov/pubmed/37693949 http://dx.doi.org/10.1016/j.omtm.2023.08.017

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