The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities

B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types, mainly through potentiating the Wnt/β-catenin signaling. However, increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles. Herein, we s...

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Autores principales: Wu, Minjie, Dong, Heng, Xu, Chao, Sun, Mengqing, Gao, Haojin, Bu, Fangtian, Chen, Jianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491870/
https://www.ncbi.nlm.nih.gov/pubmed/37692512
http://dx.doi.org/10.1016/j.gendis.2023.03.012
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author Wu, Minjie
Dong, Heng
Xu, Chao
Sun, Mengqing
Gao, Haojin
Bu, Fangtian
Chen, Jianxiang
author_facet Wu, Minjie
Dong, Heng
Xu, Chao
Sun, Mengqing
Gao, Haojin
Bu, Fangtian
Chen, Jianxiang
author_sort Wu, Minjie
collection PubMed
description B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types, mainly through potentiating the Wnt/β-catenin signaling. However, increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles. Herein, we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular, physiological, or pathological processes. Moreover, we also concluded that the targeted inhibitors disrupt the interaction of β-catenin with BCL9 reported recently.
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spelling pubmed-104918702023-09-10 The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities Wu, Minjie Dong, Heng Xu, Chao Sun, Mengqing Gao, Haojin Bu, Fangtian Chen, Jianxiang Genes Dis Review Article B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and a well-established oncogenic driver in multiple cancer types, mainly through potentiating the Wnt/β-catenin signaling. However, increasing evidences indicate that BCL9 also plays multiple Wnt-independent roles. Herein, we summarized the updates of the canonical and non-canonical functions of BCL9 in cellular, physiological, or pathological processes. Moreover, we also concluded that the targeted inhibitors disrupt the interaction of β-catenin with BCL9 reported recently. Chongqing Medical University 2023-04-11 /pmc/articles/PMC10491870/ /pubmed/37692512 http://dx.doi.org/10.1016/j.gendis.2023.03.012 Text en © 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Wu, Minjie
Dong, Heng
Xu, Chao
Sun, Mengqing
Gao, Haojin
Bu, Fangtian
Chen, Jianxiang
The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title_full The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title_fullStr The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title_full_unstemmed The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title_short The Wnt-dependent and Wnt-independent functions of BCL9 in development, tumorigenesis, and immunity: Implications in therapeutic opportunities
title_sort wnt-dependent and wnt-independent functions of bcl9 in development, tumorigenesis, and immunity: implications in therapeutic opportunities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491870/
https://www.ncbi.nlm.nih.gov/pubmed/37692512
http://dx.doi.org/10.1016/j.gendis.2023.03.012
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