Cargando…

Mapk7 deletion in chondrocytes causes vertebral defects by reducing MEF2C/PTEN/AKT signaling

Mutation of the MAPK7 gene was related to human scoliosis. Mapk7 regulated the development of limb bones and skulls in mice. However, the role of MAPK7 in vertebral development is still unclear. In this study, we constructed Col2a1-cre; Mapk7(f/f) transgenic mouse model to delete Mapk7 in cartilage,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Chengzhi, Liu, Hengyu, Zhong, Dongmei, Yang, Xiaoming, Liao, Zhiheng, Chen, Yuyu, Zhang, Shun, Su, Deying, Zhang, Baolin, Li, Chuan, Tian, Liru, Xu, Caixia, Su, Peiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2023
Materias:	Full Length Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491872/ https://www.ncbi.nlm.nih.gov/pubmed/37692479 http://dx.doi.org/10.1016/j.gendis.2023.02.012

Ejemplares similares

Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia
por: Yang, Xiaoming, et al.
Publicado: (2020)

Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis
por: Chen, Yuyu, et al.
Publicado: (2022)

Dihydroartemisinin Attenuated Intervertebral Disc Degeneration via Inhibiting PI3K/AKT and NF-κB Signaling Pathways
por: Liao, Zhiheng, et al.
Publicado: (2022)

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration
por: Wu, Jinna, et al.
Publicado: (2022)

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution
por: Zhou, Taifeng, et al.
Publicado: (2023)

Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf
por: Chen, Yuyu, et al.
Publicado: (2023)

Dual novel mutations in SLC26A2 in two siblings with multiple epiphyseal dysplasia 4 from a Chinese family: a case report
por: Zhou, Taifeng, et al.
Publicado: (2018)

Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution
por: Wu, Wenwu, et al.
Publicado: (2011)

Predicted transmembrane proteins with homology to Mef(A) are not responsible for complementing mef(A) deletion in the mef(A)–msr(D) macrolide efflux system in Streptococcus pneumoniae
por: Fox, Valeria, et al.
Publicado: (2021)

Targeting miR-18a sensitizes chondrocytes to anticytokine therapy to prevent osteoarthritis progression
por: Lian, Chengjie, et al.
Publicado: (2020)

Analysis of the morphometric change in the uncinate process of the cervical spondylosis patients: A study of radiological anatomy
por: Cui, Shangbin, et al.
Publicado: (2020)

Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy
por: Duan, Mengmeng, et al.
Publicado: (2023)

Estrogen promotes the onset and development of idiopathic scoliosis via disproportionate endochondral ossification of the anterior and posterior column in a bipedal rat model
por: Zheng, Shuhui, et al.
Publicado: (2018)

MET mutation causes muscular dysplasia and arthrogryposis
por: Zhou, Hang, et al.
Publicado: (2019)

PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway
por: Wang, Wenda, et al.
Publicado: (2020)

A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud
por: Xu, Caixia, et al.
Publicado: (2019)

Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling
por: Wales, Stephanie, et al.
Publicado: (2014)

Collagen type II suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1−SMAD1 interaction
por: Lian, Chengjie, et al.
Publicado: (2019)

Osteopontin (OPN) alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes
por: Luo, Wei, et al.
Publicado: (2022)

The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing
por: Kodama, Joe, et al.
Publicado: (2022)

Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication
por: Zhong, Yingqian, et al.
Publicado: (2023)

Aptamer engineering exosomes loaded on biomimetic periosteum to promote angiogenesis and bone regeneration by targeting injured nerves via JNK3 MAPK pathway
por: Su, Yanlin, et al.
Publicado: (2022)

Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification
por: Rashid, Harunur, et al.
Publicado: (2021)

Targeted Deletion of Los1 Homologue Affects the Production of a Recombinant Model Protein in Pichia pastoris
por: Zarei, Najmeh, et al.
Publicado: (2021)

Suitable characteristics in the selection of human allogeneic chondrocytes donors to increase the number of viable cells for cartilage repair
por: Olivos-Meza, Anell, et al.
Publicado: (2023)

Chondrocyte targeting gold nanoparticles protect growth plate against inflammatory damage by maintaining cartilage balance
por: Bai, Xue, et al.
Publicado: (2023)

DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression
por: Chen, Jinnan, et al.
Publicado: (2023)

Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling
por: Zhou, Ya, et al.
Publicado: (2019)

Microfluidic nutrient gradient–based three-dimensional chondrocyte culture-on-a-chip as an in vitro equine arthritis model
por: Rosser, J., et al.
Publicado: (2019)

Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation
por: Hussein, Amira I., et al.
Publicado: (2023)

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization
por: Fan, Mengtian, et al.
Publicado: (2022)

Broccoli, PTEN deletion and prostate cancer: where is the link?
por: Appendino, Giovanni, et al.
Publicado: (2010)

FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
por: Kan, Shiyi, et al.
Publicado: (2023)

Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb
por: Ganassi, M., et al.
Publicado: (2014)

MEF2 signaling and human diseases
por: Chen, Xiao, et al.
Publicado: (2017)

Construction of Various γ34.5 Deleted Fluorescent-Expressing Oncolytic herpes Simplex type 1 (oHSV) for Generation and Isolation of HSV-Based Vectors
por: Abdoli, Shahriyar, et al.
Publicado: (2017)

Correction: FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
por: Kan, Shiyi, et al.
Publicado: (2023)

Prevention of vertebral body–splitting fractures after multilevel ProDisc-L implantation
por: Sullivan, Humbert G., et al.
Publicado: (2012)

Vertebral pattern variation in the North Sea harbor porpoise (Phocoena phocoena) by computed tomography
por: Willems, Dorien S., et al.
Publicado: (2020)

PTEN-induced putative kinase 1 regulates mitochondrial quality control and is essential for the maturation of human induced pluripotent stem cell-derived cardiomyocytes
por: Liu, Huiwen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_b5r1l6e0d5mm566abr12gcj725