Signaling pathways governing the behaviors of leukemia stem cells

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies...

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Detalles Bibliográficos
Autores principales: Azizidoost, Shirin, Nasrolahi, Ava, Sheykhi-Sabzehpoush, Mohadeseh, Anbiyaiee, Amir, Khoshnam, Seyed Esmaeil, Farzaneh, Maryam, Uddin, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10491880/
https://www.ncbi.nlm.nih.gov/pubmed/37692500
http://dx.doi.org/10.1016/j.gendis.2023.01.008
Descripción
Sumario:Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow. Although various treatment options have been used for different types of leukemia, understanding the molecular pathways involved in the development and progression of leukemia is necessary. Recent studies showed that leukemia stem cells (LSCs) play essential roles in the pathogenesis of leukemia by targeting several signaling pathways, including Notch, Wnt, Hedgehog, and STAT3. LSCs are highly proliferative cells that stimulate tumor initiation, migration, EMT, and drug resistance. This review summarizes cellular pathways that stimulate and prevent LSCs' self-renewal, metastasis, and tumorigenesis.

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